Objectives This review highlights aspects of drug hydrophobicity and lipophilicity as
determinants of different oral formulation approaches with specific focus on enabling …

Objectives Solubility parameters have been used for decades in various scientific fields
including pharmaceutics. It is, however, still a field of active research both on a conceptual …

The purpose of this study was to combine direct powder extrusion (DPE) 3D printing and
fluid bed coating techniques to create a budesonide (BD) loaded solid oral formulations for …

Amorphous solid dispersions (ASD) are increasingly used to improve the oral bioavailability
of poorly water-soluble compounds. However, hydrophilic polymers in ASD have high water …

Posaconazole (PCZ) and benznidazole (BNZ) are known to show synergetic effect in
treating the acute and chronic phases of Chagas disease, a neglected parasitic disease …

Hot-melt extrusion is an option to fabricate amorphous solid dispersions and to enhance oral
bioavailability of poorly soluble compounds. The selection of suitable polymer carriers and …

This chapter provides an overview of the importance and relevance of solid state properties
in different phases of drug product development. The galenical tetrahedron outlines the …

Poor bioavailability of a drug, ie a low fraction of the administered dose reaching the
systemic circulation, may result not only in the lack of pharmacological effect but also in …

In spite of various contemporary medicinal approaches developed, there are still more than
40% of drugs in the pharmaceutic market and more than 70% of the drug candidates are …