An underutilized bean: hyacinth bean [Lablab purpureus (L.) sweet]: bioactive compounds, functional activity, and future food prospect and applications
J Zhou, W Wang, Z Zhang, G Zhu, J Qiao… - Journal of the …, 2024 - Wiley Online Library
Hyacinth bean [Lablab purpureus (L.) Sweet], a plant belonging to the leguminous family
and traditionally used for medicinal purposes in China, is a valuable resource with a wide …
and traditionally used for medicinal purposes in China, is a valuable resource with a wide …
Antidiabetic potential of thiazolidinedione derivatives with efficient design, molecular docking, structural activity relationship, and biological activity: an update review …
Thiazolidinedione has been used successfully by medicinal chemists all over the world in
the development of potent antidiabetic derivatives. The few compounds with excellent …
the development of potent antidiabetic derivatives. The few compounds with excellent …
A new molecular structure and computational analyses: DFT Studies, NLO Properties, ADMET predictions, biological targets, and docking experiments
S Şahin - Polycyclic Aromatic Compounds, 2024 - Taylor & Francis
In this study, synthesis, characterization, optical, and in silico medicinal properties of a Schiff
base compound, 4-((4, 5-difluoro-2-hydroxybenzylidene) amino)-1, 5-dimethyl-2-phenyl-2, 3 …
base compound, 4-((4, 5-difluoro-2-hydroxybenzylidene) amino)-1, 5-dimethyl-2-phenyl-2, 3 …
Computational analysis of potential drug-like compounds from Solanum torvum - A promising phytotherapeutics approach for the treatment of diabetes
AA Choudhury, DR V - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Diabetes mellitus (DM) is a global pandemic that is characterized by high blood glucose
levels. Conventional treatments have limitations, leading to the search for natural …
levels. Conventional treatments have limitations, leading to the search for natural …
[HTML][HTML] Chaotic neural network algorithm with competitive learning integrated with partial Least Square models for the prediction of the toxicity of fragrances in …
M Lephalala, SS Vives, K Bisetty - Science of the Total Environment, 2024 - Elsevier
This study addresses the need for accurate structural data regarding the toxicity of
fragrances in sanitizers and disinfectants. We compare the predictive and descriptive (model …
fragrances in sanitizers and disinfectants. We compare the predictive and descriptive (model …
Synthesis of thiazolidine-2, 4-dione tethered 1, 2, 3-triazoles as α-amylase inhibitors: In vitro approach coupled with QSAR, molecular docking, molecular dynamics …
A new series of thiazolidine-2, 4-dione tethered 1, 2, 3-triazole derivatives were designed,
synthesized and screened for their α-amylase inhibitory potential employing in vitro and in …
synthesized and screened for their α-amylase inhibitory potential employing in vitro and in …
Thiazolidinedione–triazole conjugates: design, synthesis and probing of the α-amylase inhibitory potential
Aim: The primary objective of this investigation was the synthesis, spectral interpretation and
evaluation of the α-amylase inhibition of rationally designed thiazolidinedione–triazole …
evaluation of the α-amylase inhibition of rationally designed thiazolidinedione–triazole …
Design, synthesis, molecular dynamic simulation, DFT analysis, computational pharmacology and decoding the antidiabetic molecular mechanism of sulphonamide …
SD Ranade, SG Alegaon, NA Khatib, S Gharge… - Journal of Molecular …, 2024 - Elsevier
In search of novel antidiabetic agents, the study was framed to hybridize and synthesize
molecules based on scaffolds of benzenesulfonamide and thiazolidine-4-one, efficiently …
molecules based on scaffolds of benzenesulfonamide and thiazolidine-4-one, efficiently …
[HTML][HTML] Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and …
P Seboletswe, G Kumar, L Kubone, K Olofinsan… - Medicinal Chemistry …, 2024 - Springer
Diabetes mellitus (DM) has become a growing concern to global public health, being at the
forefront of acute disorders and causes of mortality across the globe. Clinically approved …
forefront of acute disorders and causes of mortality across the globe. Clinically approved …
Finding structural requirements of structurally diverse α-glucosidase and α-amylase inhibitors through validated and predictive 2D-QSAR and 3D-QSAR analyses
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemic state.
The α-glucosidase and α-amylase are considered two major targets for the management of …
The α-glucosidase and α-amylase are considered two major targets for the management of …