A review of in silico research, SARS-CoV-2, and neurodegeneration: focus on papain-like protease

AS Rieder, BF Deniz, CA Netto, ATS Wyse - Neurotoxicity Research, 2022 - Springer
Since the appearance of SARS-CoV-2 and the COVID-19 pandemic, the search for new
approaches to treat this disease took place in the scientific community. The in silico …

Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic …

E Pitsillou, J Liang, K Ververis, A Hung… - Journal of Molecular …, 2021 - Elsevier
The SARS-CoV-2 virus is causing COVID-19, an ongoing pandemic, with extraordinary
global health, social, and political implications. Currently, extensive research and …

In silico identification of potential inhibitors of SARS-CoV-2 papain-like protease from natural sources: A natural weapon to fight COVID-19

B Debnath, P Debnath, R Ghosh, S Debnath - Coronaviruses, 2021 - ingentaconnect.com
Background: The rapid spread of the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) globally has created unprecedented health care and economic crisis. The …

Search for novel potent inhibitors of the SARS-CoV-2 papain-like enzyme: A computational biochemistry approach

MI Osorio, O Yáñez, M Gallardo, M Zuñiga-Bustos… - Pharmaceuticals, 2022 - mdpi.com
The rapid emergence and spread of new variants of coronavirus type 2, as well as the
emergence of zoonotic viruses, highlights the need for methodologies that contribute to the …

[HTML][HTML] Virtual screening of natural metabolites and antiviral drugs with potential inhibitory activity against 3CL-PRO and PL-PRO

N Contreras-Puentes… - Biomedical and …, 2020 - biomedpharmajournal.org
Aims: COVID-19 is a global pandemic that has affected around 186 countries in the world,
related to clinical signs as fever, cough and pneumonia. The disease is caused by SARS …

SARS-CoV-2 Papain-like Protease as a Target for Anti-HCV and Anti-HIV Proteases: In silico Perspective.

AA Elfiky - Systematic Reviews in Pharmacy, 2022 - search.ebscohost.com
The papain-like protease (PLpro) is a useful target for discovering SARS-CoV-2
therapeutics. This study targets the newly emerged SARS-CoV-2 PLpro by anti-SARS-CoV …

Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV‐2: A repurposing study

G Ribaudo, X Yun, A Ongaro… - Chemical Biology & …, 2023 - Wiley Online Library
The development of inhibitors that target the papain‐like protease (PLpro) has the potential
to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV …

Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach

M Sencanski, V Perovic, J Milicevic… - …, 2022 - Wiley Online Library
In the current pandemic, finding an effective drug to prevent or treat the infection is the
highest priority. A rapid and safe approach to counteract COVID‐19 is in silico drug …

Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro …

E Pitsillou, J Liang, K Ververis, KW Lim, A Hung… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political,
socio-economic, and public health consequences. Inhibiting replication represents an …

Potential papain-like protease inhibitors against COVID-19: a Comprehensive in Silico Based Review

N Agrawal, S Pathak, A Goyal - Combinatorial chemistry & high …, 2022 - ingentaconnect.com
The entire world has been in a battle against the COVID-19 pandemic since its first
appearance in December 2019. Thus researchers are desperately working to find an …