Inflammasomes are an essential part of the innate immune system. They are necessary for
the development of a healthy immune response against infectious diseases. Inflammasome …

Inflammatory responses are essential in eliminating harmful substrates from damaged tissue
and inducing recovery. Several cytokines participate in and facilitate this response. Certain …

Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a
pivotal role by contributing to innate and adaptive immune responses. Inflammasomes are …

The innate immune system serves to generate immediate host defenses against pathogens.
Advance in the mechanism of innate immunity has provided new insights into host-pathogen …

Activation of the inflammasome occurs in response to infection with a wide array of
pathogenic microbes. The inflammasome serves as a platform to activate caspase-1, which …

The innate immune system is a dynamic and complex network for recognizing and
responding to cellular insult or tissue damage after infection or injury. The primary effector …

Inflammatory response is initiated and sustained by the action of quintessential pro-
inflammatory cytokines of immune system namely IL-1β and IL-18. The maturation process …

Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response
to a number of exogenous and endogenous danger signals, leading to the production of pro …

Highlights•The innate immune system utilizes a set of multiprotein complexes called
inflammasomes that can be triggered during infection.•Inflammasome activation supports …

The inflammasome is a large multiprotein complex whose assembly leads to the activation
of caspase-1, which promotes the maturation of proinflammatory cytokines interleukin-1β (IL …