Herein, we reported a new bergenin: 4-aminobenzamide (BGN-4AM) cocrystal with
significantly enhanced solubility and low hygroscopicity probed from two aspects such as …

Bergenin (BER) is a bioactive compound used for the treatment of chronic bronchitis in
China. However, its low solubility and permeation limits its oral bioavailability. In this study, a …

Bergenin is neither a highly lipophilic nor a highly hydrophilic bioactive compound due to
which its dissolution and permeation are poor which results in poor oral bioavailability. The …

The impact of pharmaceutical co-crystallization with pyromellitic dianhydride (PMDA) on the
aqueous solubility of the poorly water-soluble drug Berberine (Bb+), an isoquinoline alkaloid …

Physicochemical properties of bergenin, namely the solid state characteristics, solution
stability, dissociation constant (pKa), solubility and octanol/water partition coefficient (Log P) …

Abstract Carbamazepine (CBZ), a Biopharmaceutics Classification System (BCS) class II
drug, is widely-used as a first line antiepileptic drug. Numbers of cocrystals have reported to …

BBC is a drug with a variety of activities but poor solubility. Cocrystal technology is an
effective method to improve the solubility and stability of this type of compound. In this work …

Blonanserin (BLN) is an antipsychotic drug having poor aqueous solubility. In continuation
of our preliminary work (CrystEngComm 2012, 14, 2367− 2372), the aim of this study was to …

Cocrystals of a nonionizable, water soluble compound (gababentin lactam (GBPL)) with less
soluble coformers, are shown to be 2 to 17 times less soluble than GBPL. Cocrystals of …

The cosolvency action of dimethyl sulfoxide (DMSO) in solubility enhancement and
thermodynamic function of drugs had rarely been investigated in literature. Hence, in the …