[HTML][HTML] Microarray patches enable the development of skin-targeted vaccines against COVID-19

E Korkmaz, SC Balmert, TL Sumpter, CD Carey… - Advanced drug delivery …, 2021 - Elsevier
The COVID-19 pandemic is a serious threat to global health and the global economy. The
ongoing race to develop a safe and efficacious vaccine to prevent infection by SARS-CoV-2 …

Microarray patches: scratching the surface of vaccine delivery

JJY Choo, CLD McMillan, PR Young… - Expert Review of …, 2023 - Taylor & Francis
Introduction Microneedles are emerging as a promising technology for vaccine delivery, with
numerous advantages over traditional needle and syringe methods. Preclinical studies have …

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

CLD McMillan, JJY Choo, A Idris, A Supramaniam… - Science …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
160 million people and resulted in more than 3.3 million deaths, and despite the availability …

COVID-19 vaccines and the skin: the landscape of cutaneous vaccine reactions worldwide

Q Sun, R Fathy, DE McMahon… - Dermatologic clinics, 2021 - derm.theclinics.com
As of April 22, 2021, the novel coronavirus disease 2019 (COVID-19) has sickened more
than 142 million people and taken more than 3 million lives worldwide. 1 Although …

A Single‐Administration Microneedle Skin Patch for Multi‐Burst Release of Vaccine against SARS‐CoV‐2

KTM Tran, TD Gavitt, TT Le, A Graichen… - Advanced Materials …, 2023 - Wiley Online Library
The necessity for multiple injections and cold‐chain storage has contributed to suboptimal
vaccine utilization, especially in pandemic situations. Thermally‐stable and single …

[HTML][HTML] The skin as a critical window in unveiling the pathophysiologic principles of COVID-19

C Magro, G Nuovo, JJ Mulvey, J Laurence, J Harp… - Clinics in …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of
coronavirus disease 2019 (COVID-19), is a single-stranded RNA virus whose sequence is …

Engineering immunity via skin-directed drug delivery devices

S Polaka, V Makwana, N Vasdev, A Sheth… - Journal of Controlled …, 2022 - Elsevier
Extensive research is underway to discover a safe and effective vehicle to deliver the
vaccines at the desired cutaneous site. These efforts majorly comprise the development of a …

Vaccination into the dermal compartment: techniques, challenges, and prospects

J Hettinga, R Carlisle - Vaccines, 2020 - mdpi.com
In 2019, an 'influenza pandemic'and 'vaccine hesitancy'were listed as two of the top 10
challenges to global health by the WHO. The skin is a unique vaccination site, due to its …

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

E Kim, G Erdos, S Huang, TW Kenniston, SC Balmert… - …, 2020 - thelancet.com
Background Coronaviruses pose a serious threat to global health as evidenced by Severe
Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and …

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

GJP Fernando, X Chen, TW Prow, ML Crichton… - PloS one, 2010 - journals.plos.org
Background Over 14 million people die each year from infectious diseases despite
extensive vaccine use. The needle and syringe—first invented in 1853—is still the primary …