AS03 is an Adjuvant System composed of α-tocopherol, squalene and polysorbate 80 in an
oil-in-water emulsion. In various nonclinical and clinical studies, high levels of antigen …

AS03 is an Adjuvant System (AS) containing α-tocopherol and squalene in an oil-in-water
(o/w) emulsion. AS03 has been considered for the development of pandemic and seasonal …

Background. The tocopherol-based oil-in-water emulsion adjuvant system family (AS03)
improves antigen sparing with split-virion H5N1 influenza vaccines, representing an …

The development of adjuvants will represent a major challenge for this century. Indeed the
need for safer vaccines leads to the development of a new generation of antigens like …

Oil-in-water emulsions have gained consideration as vaccine adjuvants in recent years due
to their ability to elicit a differentiated immunogenic response compared to traditional …

Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as
key components of licensed vaccines, with over 100 million doses administered to diverse …

Oil-in-water emulsions have shown promise as safe and effective adjuvant formulations for
vaccines. In particular, formulations consisting of metabolizable oils such as shark-derived …

Adjuvant System AS01 is a liposome-based vaccine adjuvant containing 3-O-desacyl-4′-
monophosphoryl lipid A and the saponin QS-21. AS01 has been selected for the clinical …

The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been
administered to more than 100 million people in more than 30 countries, in both seasonal …

The immunostimulants 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …