Background Vaccines are the main prophylactic measure against pandemic influenza.
Adjuvanted, cell culture–derived vaccines, which are not subject to limitations of egg-based …

Abstract Background. A/H3N2 variant (H3N2v) influenza may sustain human-to-human
transmission, and an available candidate vaccine would be important. Methods. In this …

Background: A/H5N1 influenza virus has significant pandemic potential, and vaccination is
the main prophylactic measure. This phase 2, randomized, observer-blind, multicenter study …

Abstract Background A/H5N1 influenza viruses have high pandemic potential; consequently,
vaccines need to be produced rapidly. MF59® adjuvant reduces the antigen required per …

Background: Vaccines against pandemic A/H1N1 influenza should provide protective
immunity in children, because they are at greater risk of disease than adults. This study was …

Objectives This study was designed to identify the optimal dose of an MF59®-adjuvanted,
monovalent, A/H1N1 influenza vaccine in healthy paediatric subjects. Methods Subjects …

Mass immunization of children has the potential to decrease infection rates and prevent the
transmission of influenza. We evaluated the immunogenicity, safety, and tolerability of …

Background We conducted a phase I/II clinical trial to evaluate the safety and
immunogenicity of a Madin-Darby canine kidney (MDCK) cell-grown inactivated H7N9 …

INTRODUCTION: Effective vaccination strategies are required to combat future influenza
pandemics. Here we report the results of three independent clinical trials performed in …

Background. Children are highly vulnerable to infection with novel influenza viruses. It is
essential to develop candidate pandemic influenza vaccines that are safe and effective in …