Emerging advances in delivery systems for mRNA cancer vaccines

Z Jiang, Y Xu, G Du, X Sun - Journal of Controlled Release, 2024 - Elsevier
The success of lipid nanoparticles (LNPs) in treating COVID-19 promotes further research of
mRNA vaccines for cancer vaccination. Aiming at overcoming the constraints of currently …

Nanoparticle‐Based mRNA Vaccines: Are We One Step Closer to Targeted Cancer Therapy?

LV Nalla, SN Gajula, VP Chavda - … ‐Based Fast Track …, 2024 - Wiley Online Library
Messenger RNA (mRNA) has recently become a compelling alternative for treating and
preventing cancers with substantial therapeutic outcomes. In vitro transcription of mRNA has …

Lipid Nanoparticle-Based Delivery System─ A Competing Place for mRNA Vaccines

X Zhang, Y Li, Z Zhou - ACS omega, 2024 - ACS Publications
mRNA, as one of the foci of biomedical research in the past decade, has become a
candidate vaccine solution for various infectious diseases and tumors and for regenerative …

Advanced nanoscale delivery systems for mRNA-based vaccines

M Mobasher, R Ansari, AM Castejon, J Barar… - Biochimica et Biophysica …, 2024 - Elsevier
The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for
COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of …

Nanoparticles as adjuvants and nanodelivery systems for mRNA-based vaccines

IM Alfagih, B Aldosari, B AlQuadeib, A Almurshedi… - Pharmaceutics, 2020 - mdpi.com
Messenger RNA (mRNA)-based vaccines have shown promise against infectious diseases
and several types of cancer in the last two decades. Their promise can be attributed to their …

Advances in mRNA vaccines

M Li, Z Wang, C Xie, X Xia - International Review of Cell and Molecular …, 2022 - Elsevier
Abstract mRNA vaccines have been increasingly recognized as a powerful vaccine platform
since the FDA approval of two COVID-19 mRNA vaccines, which demonstrated outstanding …

Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

EH Pilkington, EJA Suys, NL Trevaskis, AK Wheatley… - Acta biomaterialia, 2021 - Elsevier
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …

Cancer mRNA vaccines: clinical advances and future opportunities

EJ Sayour, D Boczkowski, DA Mitchell… - Nature Reviews Clinical …, 2024 - nature.com
Abstract mRNA vaccines have been revolutionary in terms of their rapid development and
prevention of SARS-CoV-2 infections during the COVID-19 pandemic, and this technology …

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

L Wu, X Li, X Qian, S Wang, J Liu, J Yan - Vaccines, 2024 - mdpi.com
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …