Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia
The present review article summarizes and expands upon the discussions that were initiated
during a meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition …
during a meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition …
Impairments in both reward and punishment guided reinforcement learning in schizophrenia.
G Fervaha, O Agid, G Foussias… - Schizophrenia …, 2013 - psycnet.apa.org
The primary outcome for the present analysis was performance on the test phase of the task
which tests for reward-driven and punishment-driven learning. An additional three …
which tests for reward-driven and punishment-driven learning. An additional three …
Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction
BACKGROUND: Rewards and punishments may make distinct contributions to learning via
separate striatal-cortical pathways. We investigated whether fronto-striatal dysfunction in …
separate striatal-cortical pathways. We investigated whether fronto-striatal dysfunction in …
Translational rodent paradigms to investigate neuromechanisms underlying behaviors relevant to amotivation and altered reward processing in schizophrenia
JW Young, A Markou - Schizophrenia bulletin, 2015 - academic.oup.com
Amotivation and reward-processing deficits have long been described in patients with
schizophrenia and considered large contributors to patients' inability to integrate well in …
schizophrenia and considered large contributors to patients' inability to integrate well in …
General functioning predicts reward and punishment learning in schizophrenia
Previous studies investigating feedback-driven reinforcement learning in patients with
schizophrenia have provided mixed results. In this study, we explored the clinical predictors …
schizophrenia have provided mixed results. In this study, we explored the clinical predictors …
Intrinsic and extrinsic motivation and learning in schizophrenia
LC Kremen, JM Fiszdon, MM Kurtz… - Current Behavioral …, 2016 - Springer
Conceptually, motivation can be separated into two types, intrinsic and extrinsic. Intrinsic
motivation involves goal-directed behaviors that meet internal psychological needs, while …
motivation involves goal-directed behaviors that meet internal psychological needs, while …
From neuroimaging to daily functioning: A multimethod analysis of reward anticipation in people with schizophrenia.
EK Moran, AJ Culbreth, S Kandala… - Journal of abnormal …, 2019 - psycnet.apa.org
Negative symptoms are a core clinical feature of schizophrenia that are only marginally
responsive to current treatments. Recent work suggests that deficits in reinforcement …
responsive to current treatments. Recent work suggests that deficits in reinforcement …
Explicit and implicit reinforcement learning across the psychosis spectrum.
Motivational and hedonic impairments are core features of a variety of types of
psychopathology. An important aspect of motivational function is reinforcement learning …
psychopathology. An important aspect of motivational function is reinforcement learning …
Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia
BACKGROUND:: Negative symptoms are core features of schizophrenia (SZ); however, the
cognitive and neural basis for individual negative symptom domains remains unclear …
cognitive and neural basis for individual negative symptom domains remains unclear …
Reinforcement learning and dopamine in schizophrenia: dimensions of symptoms or specific features of a disease group?
Abnormalities in reinforcement learning are a key finding in schizophrenia and have been
proposed to be linked to elevated levels of dopamine neurotransmission. Behavioral deficits …
proposed to be linked to elevated levels of dopamine neurotransmission. Behavioral deficits …
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