We report the development of chimeric DNA binding peptides comprising a DNA binding
fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric …

Transcription factors are DNA-binding proteins responsible for initiating the transcription of
particular genes upon interacting with specific DNA sequences located at their promoter or …

Most transcription factors (TFs) bind specific DNA sequences using dimeric or multimer
motifs, with more or less equal binding energy contributions from each domain and usually …

Sequence-specific DNA binding of the gene regulatory protein is often mediated by dimeric
species. Recent studies on the action of basic-helix-loop-helix and basic-leucine-zipper …

Artificial DNA binding peptides recognizing separated sequences would expand varieties of
the target genes for desirable transcriptional control. Here we demonstrated that …

One of the strategies used by nature to regulate gene expression relies on the stimuli-
controlled combination of DNA-binding proteins. This in turn determines the target-binding …

Transcription factors (TFs) are specialized proteins that play a key role in the regulation of
genetic expression. Their mechanism of action involves the interaction with specific DNA …

Typical eukaryotic transcriptional activators are composed of distinct functional domains,
including a DNA binding domain and an activating domain. Artificial transcription factors …

We report the rational design of a DNA-binding peptide construct composed of the DNA-
contacting regions of two transcription factors (GCN4 and GAGA) linked through an AT-hook …

The interaction of transcription factors with specific DNA sites is key for the regulation of
gene expression. Despite the availability of a large body of structural data on protein–DNA …