Nuclear bodies (NBs) are structures that concentrate proteins, RNAs, and
ribonucleoproteins that perform functions essential to gene expression. How NBs assemble …

Nuclear bodies are protein-and RNA-containing structures that participate in a wide range of
processes critical to genome function. Molecular self-organization is thought to drive nuclear …

The histone locus body (HLB) is an evolutionarily conserved nuclear body that regulates the
transcription and processing of replication-dependent (RD) histone mRNAs, which are the …

Nuclear protein, ataxia-telangiectasia locus (NPAT) and FLICE-associated huge protein
(FLASH) are two major components of discrete nuclear structures called histone locus …

Many membraneless organelles form through liquid-liquid phase separation, but how their
size is controlled and whether size is linked to function remain poorly understood. The …

Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-
dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that …

Cyclin E/Cdk2 is necessary for replication-dependent histone mRNA biosynthesis, but how it
controls this process in early development is unknown. We show that in Drosophila embryos …

Compartmentalization of RNA biosynthetic factors into nuclear bodies (NBs) is a ubiquitous
feature of eukaryotic cells. How NBs initially assemble and ultimately affect gene expression …

The conserved histone locus body (HLB) assembles prior to zygotic gene activation early
during development and concentrates factors into a nuclear domain of coordinated histone …

The histone locus body (HLB) assembles at replication-dependent (RD) histone loci and
concentrates factors required for RD histone mRNA biosynthesis. The Drosophila …