Harnessing the power of fungal siderophores for the imaging and treatment of human diseases
A Szebesczyk, E Olshvang, A Shanzer… - Coordination chemistry …, 2016 - Elsevier
Innovative strategies are needed to address the current lack of clinically available antifungal
drugs and for diagnostic techniques.'Repurposing'of antifungal drugs, similar to techniques …
drugs and for diagnostic techniques.'Repurposing'of antifungal drugs, similar to techniques …
Siderophores for medical applications: imaging, sensors, and therapeutics
D Fan, Q Fang - International Journal of Pharmaceutics, 2021 - Elsevier
Siderophores are low-molecular-weight chelators produced by microorganisms to scavenge
iron from the environment and deliver it to cells via specific receptors. Tremendous …
iron from the environment and deliver it to cells via specific receptors. Tremendous …
Siderophore-based detection of Fe(iii) and microbial pathogens
T Zheng, EM Nolan - Metallomics, 2012 - academic.oup.com
Siderophores are low-molecular-weight iron chelators that are produced and exported by
bacteria, fungi and plants during periods of nutrient deprivation. The structures, biosynthetic …
bacteria, fungi and plants during periods of nutrient deprivation. The structures, biosynthetic …
Siderophores: A Case Study in Translational Chemical Biology
AR LeBlanc, WM Wuest - Biochemistry, 2024 - ACS Publications
Siderophores are metal-binding secondary metabolites that assist in iron homeostasis and
have been of interest to the scientific community for the last half century. Foundational …
have been of interest to the scientific community for the last half century. Foundational …
Siderophore-based molecular imaging of fungal and bacterial infections—current status and future perspectives
Invasive fungal infections such as aspergillosis are life-threatening diseases mainly affecting
immuno-compromised patients. The diagnosis of fungal infections is difficult, lacking …
immuno-compromised patients. The diagnosis of fungal infections is difficult, lacking …
Exploiting bacterial iron acquisition: siderophore conjugates
Siderophores are chelators synthesized by bacteria and fungi to sequester iron, which is
essential for virulence and pathogenicity. Since the process involves active transport, which …
essential for virulence and pathogenicity. Since the process involves active transport, which …
Siderophore-Conjugated Antifungals: A Strategy to Potentially Cure Fungal Infections
K Lakshminarayanan, D Murugan… - ACS Infectious …, 2024 - ACS Publications
Fungi pose a global threat to humankind due to the increasing emergence of multi-drug-
resistant fungi. There is a rising incidence of invasive fungal infections. Due to the structural …
resistant fungi. There is a rising incidence of invasive fungal infections. Due to the structural …
Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications
I Happacher, M Aguiar, A Yap… - Essays in …, 2023 - portlandpress.com
Iron is an essential trace element that is limiting in most habitats including hosts for fungal
pathogens. Siderophores are iron-chelators synthesized by most fungal species for high …
pathogens. Siderophores are iron-chelators synthesized by most fungal species for high …
Ferrichrome has found its match: Biomimetic Analogues with diversified activity map discrete microbial targets
J Besserglick, E Olshvang… - … A European Journal, 2017 - Wiley Online Library
Siderophores provide an established platform for studying molecular recognition principles
in biological systems. Herein, the preparation of ferrichrome (FC) biomimetic analogues …
in biological systems. Herein, the preparation of ferrichrome (FC) biomimetic analogues …
Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity
A Mular, I Hubmann, M Petrik, K Bendova… - Journal of Medicinal …, 2024 - ACS Publications
The pathogenic fungus Aspergillus fumigatus utilizes a cyclic ferrioxamine E (FOXE)
siderophore to acquire iron from the host. Biomimetic FOXE analogues were labeled with …
siderophore to acquire iron from the host. Biomimetic FOXE analogues were labeled with …