Iron is essential to nearly all life forms on Earth, required for the proper function of enzymes
involved in, for example, respiration, photosynthesis, the tricarboxylic acid cycle, nitrogen …

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic
microorganisms and their hosts. It is also a pivotal component of the innate immune …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

▪ Abstract The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and
other iron-containing proteins of their host is central to whether they live or die. To combat …

High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority
of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been …

Most of the iron in a mammalian body is complexed with various proteins. Moreover, in
response to infection, iron availability is reduced in both extracellular and intracellular …

Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However,
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …

Iron is the fourth-most abundant element on the earth, and it is needed by most organisms,
including bacteria. It exists in two oxidation states, Fe2+ and Fe3+, and is involved in many …

Iron is essential to virtually all organisms, but poses problems of toxicity and poor solubility.
Bacteria have evolved various mechanisms to counter the problems imposed by their iron …

Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …