Antibody-based immunotherapy to treat and prevent infection with hypervirulent Klebsiella pneumoniae
E Diago-Navarro, I Calatayud-Baselga… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
ABSTRACT Hypervirulent Klebsiella pneumoniae (hv Kp) strains are predicted to become a
major threat in Asia if antibiotic resistance continues to spread. Anticapsular antibodies …
major threat in Asia if antibiotic resistance continues to spread. Anticapsular antibodies …
Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2: O1 strains of Klebsiella …
PL Wantuch, CJ Knoot, LS Robinson… - PLoS …, 2023 - journals.plos.org
Klebsiella pneumoniae presents as two circulating pathotypes: classical K. pneumoniae (c
Kp) and hypervirulent K. pneumoniae (hv Kp). Classical isolates are considered urgent …
Kp) and hypervirulent K. pneumoniae (hv Kp). Classical isolates are considered urgent …
Novel, broadly reactive anticapsular antibodies against carbapenem-resistant Klebsiella pneumoniae protect from infection
E Diago-Navarro, MP Motley, G Ruiz-Peréz, W Yu… - MBio, 2018 - Am Soc Microbiol
Carbapenem-resistant (CR) sequence type 258 (ST258) Klebsiella pneumoniae has
become an urgent health care threat, causing an increasing number of high-mortality …
become an urgent health care threat, causing an increasing number of high-mortality …
Safety and Immunogenicity of Klebsiella pneumoniae K1 Capsular Polysaccharide Vaccine in Humans
SJ Cryz Jr, E Fürer, R Germanier - Journal of Infectious …, 1985 - academic.oup.com
The safety and immunogenicity of two Klebsiella pneumoniae K1 capsular polysaccharide
(CPS) vaccines were evaluated in humans. Trace quantities of lipopolysaccharide present in …
(CPS) vaccines were evaluated in humans. Trace quantities of lipopolysaccharide present in …
A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae
MF Feldman, AE Mayer Bridwell… - Proceedings of the …, 2019 - National Acad Sciences
Hypervirulent Klebsiella pneumoniae (hv Kp) is globally disseminating as a community-
acquired pathogen causing life-threatening infections in healthy individuals. The fact that a …
acquired pathogen causing life-threatening infections in healthy individuals. The fact that a …
Humoral Immunity against Capsule Polysaccharide Protects the Host from magA+Klebsiella pneumoniae-Induced Lethal Disease by Evading Toll-Like Receptor 4 …
MF Wu, CY Yang, TL Lin, JT Wang, FL Yang… - Infection and …, 2009 - Am Soc Microbiol
Klebsiella pneumoniae magA (for mucoviscosity-associated gene A) is linked to the
pathogenesis of primary pyogenic liver abscess, but the underlying mechanism by which …
pathogenesis of primary pyogenic liver abscess, but the underlying mechanism by which …
Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils
SD Kobayashi, AR Porter, B Freedman, R Pandey… - MBio, 2018 - Am Soc Microbiol
Carbapenem-resistant Klebsiella pneumoniae is a problem worldwide. A carbapenem-
resistant K. pneumoniae lineage classified as multilocus sequence type 258 (ST258) is …
resistant K. pneumoniae lineage classified as multilocus sequence type 258 (ST258) is …
Development of Klebsiella pneumoniae Capsule Polysaccharide-Conjugated Vaccine Candidates Using Phage Depolymerases
TL Lin, FL Yang, CT Ren, YJ Pan, KS Liao… - Frontiers in …, 2022 - frontiersin.org
Klebsiella pneumoniae is an important pathogen associated with nosocomial infection and
has developed increasing resistance to antibiotics such as extended-spectrum β-lactams …
has developed increasing resistance to antibiotics such as extended-spectrum β-lactams …
Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections
A Clements, AW Jenney, JL Farn, LE Brown… - Vaccine, 2008 - Elsevier
Vaccination strategies against Klebsiella pneumoniae have largely focussed on the
polysaccharide capsule. However, the large number and high prevalence of individual …
polysaccharide capsule. However, the large number and high prevalence of individual …
Interaction of multidrug-resistant hypervirulent Klebsiella pneumoniae with components of human innate host defense
FR DeLeo, AR Porter, SD Kobayashi, B Freedman… - Mbio, 2023 - Am Soc Microbiol
Klebsiella pneumoniae is an important cause of healthcare-associated infections worldwide.
This opportunistic pathogen, known as classical K. pneumoniae (cKp), typically causes …
This opportunistic pathogen, known as classical K. pneumoniae (cKp), typically causes …