Support measures currently represent the mainstay of treatment for fulminant myocarditis,
while effective and safe anti-inflammatory therapies remain an unmet clinical need …

Objective: Treatment of viral fulminant myocarditis relies on life support measures. Based on
studies pointing to a role for the proinflammatory cytokine interleukin-1 in myocardial …

Background Acute myocarditis is an inflammation of the myocardium that can cause life-
threatening events. However, anti-inflammatory strategies did not reduce the risk of clinical …

Background Heart failure (HF) is a global leading cause of mortality despite implementation
of guideline directed therapy which warrants a need for novel treatment strategies. Proof-of …

Abstract Purpose Interleukin-1 (IL-1) receptor antagonist (Ra) is a naturally occurring IL-1
blocker with a cardioprotective effect during acute myocardial infarction (AMI). Anakinra …

Myocarditis is defined by WHO as an inflammatory disease affecting the myocardium,
diagnosed by endomyocardial biopsy (EMB) using established histological, immunological …

Background Acute myocardial infarction (AMI) is the result of myocardial necrosis secondary
to ischaemia and of local and systemic inflammation that further enhances tissue damage …

Critical Care Medicine www. ccmjournal. org 1631 dose of 100 mg/d. This case's heart
function was rapidly deteriorating in spite of extracorporeal membrane oxygenation (ECMO) …

Background: Heart failure is an inflammatory disease. Patients with acute decompensated
heart failure (ADHF) exhibit significant inflammatory activity on admission. We hypothesized …

Acute myocardial infarction (AMI) and heart failure (HF) are characterized by an intense
inflammatory response that contributes to progression of the injury and dysfunction (1) …