Hepatitis C virus (HCV) harnesses host dependencies to infect human hepatocytes. We
previously identified a pivotal role of IκB kinase α (IKK-α) in regulating cellular lipogenesis …

Dendritic cells (DCs) are professional phagocytes that use innate sensing and phagocytosis
to internalize and degrade self as well as foreign material, such as pathogenic bacteria …

The nuclear factor kappa B (NF-ΚB) consists of a family of transcription factors involved in
the regulation of a wide variety of biological responses. Growing evidence support that NF …

Long term high-concentrate (HC) diet feeding induces subacute ruminal acidosis (SARA),
which is reported to trigger a pro-inflammatory response. This study aimed to investigate the …

Cholera toxin (CT) is widely used as an effective adjuvant in experimental immunology for
inducing mucosal immune responses; yet its mechanisms of adjuvant action remain …

B cells home to the lymph nodes (LNs) via high endothelial venules (HEVs) under the
guidance of chemokines, particularly CXCL13. However, as CXCL13 is not directly made in …

NF-κB inducing kinase (NIK), which is considered as the central component of the non-
canonical NF-κB pathway, has been proved to be an important target for the regulation of the …

Chronic inflammation is a common denominator linking a wide range of health conditions,
including tissue response to radiation exposure. This pilot study investigates whether …

CD24 can regulate angiogenesis, drug sensitivity and the progression of colorectal cancer
(CRC). However, whether CD24 regulates autophagy and apoptosis in CRC cells remains …

Abstract Background The IκB kinase (IKK) complex has been found to have critical functions
in cancer and the immune system. In particular, IKKα, which is a member of the IKK complex …