Obesity is a major contributor to the development of steatohepatitis and fibrosis from
nonalcoholic fatty liver disease (NAFLD). Hypoxia aggravates progression of NAFLD. In …

This study aimed to investigate whether hypoxia can affect nonalcoholic fatty liver disease
(NAFLD) progression and the associated mechanisms, specifically regarding the hypoxia …

Background Obstructive sleep apnea (OSA) is associated with the progression of non-
alcoholic fatty liver disease (NAFLD) to steatohepatitis and fibrosis. This progression …

Objective Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease.
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …

Mechanisms underlying progression of nonalcoholic fatty liver disease (NAFLD) are still
incompletely characterized. Hypoxia and hypoxia‐inducible factors (HIFs) have been …

Obstructive sleep apnea is associated with insulin resistance, lipid dysregulation, and
hepatic steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD). We have …

Hypoxia and hepatosteatosis microenvironments are fundamental traits of nonalcoholic fatty
liver disease (NAFLD). Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that …

Oxygen dynamics in the liver is a central signaling mediator controlling hepatic homeostasis,
and dysregulation of cellular oxygen is associated with liver injury. Moreover, the …

Aims Hepatocyte necroptosis is a critical event in the progression of non-alcoholic fatty liver
disease (NAFLD). Obstructive sleep apnea hypopnea syndrome (OSAHS) and chronic …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
with manifestation of over‐accumulation of fat in liver. Increasing evidences indicate that …