NF-κB, a family of transcription factors regulating diverse biological processes including
immune responses, is activated by canonical and noncanonical pathways based on …

Autoinflammatory diseases are caused by defects in genes that regulate the innate
immunity. Recently, the scope of autoinflammation has been broadened to include diseases …

NF-κB is the master regulator of the immune response and is responsible for the
transcription of hundreds of genes controlling inflammation and immunity. Activation of NF …

Reversible ubiquitin modification of cell signaling molecules has emerged as a critical
mechanism by which cells respond to extracellular stimuli. Although ubiquitination of TGF-β …

Many immune responses depend upon activation of NF-κB, an important transcription factor
in the elicitation of a cytokine response. Here we show that N4BP1 inhibits TLR-dependent …

Nuclear factor κB (NF-κB) is a key transcription factor in inflammatory immune responses
and cell survival. Multiple types of ubiquitination play critical roles in the activation of NF-κB …

The transcription factor NF-ĸB is a master regulator of the innate immune response and
plays a central role in inflammatory diseases by mediating the expression of pro …

IκBα serves as a central anchoring molecule in the sequestration of NF-κB transcription
factor in the cytoplasm. Ubiquitination-mediated IκBα degradation immediately precedes …

Transcription factor NF-κB controls the expression of multiple genes involved in immunity
and inflammation. The initial activation and duration of NF-κB signaling is regulated by …

A primary step in activating the alternative nuclear factor‐κB (NF‐κB) pathway requires NF‐
κB2/p100 processing to generate p52. In most cases, stimuli‐induced p100 processing is …