Towards patient-specific computational modelling of articular cartilage on the basis of advanced multiparametric MRI techniques

K Linka, A Schäfer, M Hillgärtner, M Itskov, M Knobe… - Scientific Reports, 2019 - nature.com
Cartilage degeneration is associated with tissue softening and represents the hallmark
change of osteoarthritis. Advanced quantitative Magnetic Resonance Imaging (qMRI) …

Multiparametric MRI and computational modelling in the assessment of human articular cartilage properties: a comprehensive approach

J Thüring, K Linka, M Itskov, M Knobe… - BioMed research …, 2018 - Wiley Online Library
Quantitative magnetic resonance imaging (qMRI) is a promising approach to detect early
cartilage degeneration. However, there is no consensus on which cartilage component …

[HTML][HTML] Machine learning-augmented and microspectroscopy-informed multiparametric MRI for the non-invasive prediction of articular cartilage composition

K Linka, J Thüring, L Rieppo, RC Aydin… - Osteoarthritis and …, 2021 - Elsevier
Background Articular cartilage degeneration is the hallmark change of osteoarthritis, a
severely disabling disease with high prevalence and considerable socioeconomic and …

Detection of early-stage degeneration in human articular cartilage by multiparametric MR imaging mapping of tissue functionality

S Nebelung, M Post, M Knobe, M Tingart, P Emans… - Scientific reports, 2019 - nature.com
To assess human articular cartilage tissue functionality by serial multiparametric quantitative
MRI (qMRI) mapping as a function of histological degeneration. Forty-nine cartilage samples …

Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

DD Chan, CP Neu - Journal of The Royal Society …, 2013 - royalsocietypublishing.org
Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical,
biomechanical, metabolic and genetic factors, which are often triggered by injury, and …

Mechanical characterization of articular cartilage by combining magnetic resonance imaging and finite-element analysis—a potential functional imaging technique

P Julkunen, RK Korhonen, MJ Nissi… - Physics in Medicine & …, 2008 - iopscience.iop.org
Magnetic resonance imaging (MRI) provides a method for non-invasive characterization of
cartilage composition and structure. We aimed to see whether T 1 and T 2 relaxation times …

Magnetic resonance imaging–based biomechanical simulation of cartilage: a systematic review

SM Seyedpour, S Nafisi, M Nabati, DM Pierce… - Journal of the …, 2022 - Elsevier
MRI-based mathematical and computational modeling studies can contribute to a better
understanding of the mechanisms governing cartilage's mechanical performance and …

T2 MR imaging vs. computational modeling of human articular cartilage tissue functionality

K Linka, M Itskov, D Truhn, S Nebelung… - Journal of the mechanical …, 2017 - Elsevier
The detection of early stages of cartilage degeneration remains diagnostically challenging.
One promising non-invasive approach is to functionally assess the tissue response to …

Machine learning prediction of collagen fiber orientation and proteoglycan content from multiparametric quantitative MRI in articular cartilage

SA Mirmojarabian, AW Kajabi… - Journal of Magnetic …, 2023 - Wiley Online Library
Background Machine learning models trained with multiparametric quantitative MRIs
(qMRIs) have the potential to provide valuable information about the structural composition …

Hybrid Data-Driven and Numerical Modeling of Articular Cartilage

SS Sajjadinia, B Carpentieri… - Big Data Analysis and …, 2024 - books.google.com
Articular cartilage (AC) is a load-bearing and lubricating soft tissue between articulating
bony ends, which under healthy conditions exhibits excellent resistance and shock …