Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of
innate immunity and cancer. Recent work has also implicated these kinases in distinctively …

The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-
inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we …

Obesity is associated with chronic low-grade inflammation that negatively impacts insulin
sensitivity. Here, we show that high-fat diet can increase NF-κB activation in mice, which …

Obesity leads to tissue inflammation and insulin resistance, which are features of metabolic
diseases such as type 2 diabetes. Chiang et al.(2009) now show that the IκB kinase IKKɛ is …

Abstract The IκB Kinase (IKK)-related kinases TBK1 and IKKɛ have essential roles as
regulators of innate immunity by modulating interferon and NF-κB signaling. Recent work …

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …

Adipocytes and adipose tissue play critical roles in the regulation of metabolic homeostasis.
In obesity and obesity-associated metabolic diseases, immune cells infiltrate into adipose …

The IκB kinase β (IKKβ) is a master kinase involved in obesity-related inflammation and
insulin resistance through nuclear factor κB dependent and independent pathways …

IκB kinase β (IKKβ), a central coordinator of inflammatory responses through activation of
nuclear factor-κB (NF-κB), has been implicated as a critical molecular link between …

It is widely believed that inflammation associated with obesity has an important role in the
development of type 2 diabetes. IκB kinase beta (IKKβ) is a crucial kinase that responds to …