Discovery of evodiamine derivatives as highly selective PDE5 inhibitors targeting a unique allosteric pocket
T Zhang, Z Lai, S Yuan, YY Huang… - Journal of medicinal …, 2020 - ACS Publications
Clinical use of phosphodiesterase-5 (PDE5) inhibitors is limited by several side effects due
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …
Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket
T Zhang, Z Lai, S Yuan, YY Huang… - Journal of …, 2020 - pubmed.ncbi.nlm.nih.gov
Clinical use of phosphodiesterase-5 (PDE5) inhibitors is limited by several side effects due
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …
Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.
T Zhang, Z Lai, S Yuan, YY Huang, G Dong… - Journal of Medicinal …, 2020 - europepmc.org
Clinical use of phosphodiesterase-5 (PDE5) inhibitors is limited by several side effects due
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …