In order to improve the antitumor potency of the natural product evodiamine, novel boron-
containing evodiamine derivatives were designed by incorporating boronic acid and …

Natural products are important sources for the development of therapeutic medicine, among
which evodia fruit has a wide range of medicinal properties in traditional Chinese medicine …

Inspired by antitumor natural product evodiamine, a series of novel bis-evodiamine
derivatives were designed and synthesized, which showed potent antitumor activity. In …

Evodiamine is a quinazolinocarboline alkaloid isolated from the fruits of traditional Chinese
herb Evodiae fructus. Previously, we identified N13-substituted evodiamine derivatives as …

Gastric cancer represents a significant health burden worldwide. Previously, inspired by the
traditional Chinese medicine Wu-Chu-Yu to treat the spleen and stomach system for …

Topoisomerase has been found extremely high level of expression in hepatocellular
carcinoma (HCC) and proven to promote the proliferation and survival of HCC. Cancer …

Natural product evodiamine is one of the most privileged scaffolds in drug discovery and is
suitable for derivatization, which can be conducted quickly for structure optimization and …

Abstract Evodiamine (1), a biologically active alkaloid isolated from Evodia rutaecarpa
(known in Chinese as Wu‐Chu‐Yu), has antioxidant, anti‐inflammatory, and anticancer …

Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In
this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one …

Traditional Chinese herbs are regarded as a new and promising source of potential anti-
cancer remedies and new chemotherapy adjuvants to enhance the efficacy of chemotherapy …