Francisella tularensis, the causative agent of tularemia, is capable of causing disease in a
multitude of mammals and remains a formidable human pathogen due to a high morbidity …

The notoriety of high-consequence human pathogens has increased in recent years and,
rightfully, research efforts have focused on understanding host-pathogen interactions …

Francisella tularensis is an intracellular Gram-negative bacterium that causes life-
threatening tularemia. Although the prevalence of natural infection is low, F. tularensis …

Francisella tularensis is a category A bioterrorism agent. It is the etiological agent of
tularemia, a zoonotic disease found throughout the northern hemisphere. The intentional …

Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

In vitro experimental evolution has complemented clinical studies as an excellent tool to
identify genetic changes responsible for the de novo evolution of antimicrobial resistance …

Tularemia, caused by Francisella tularensis, is endemic to the northern hemisphere. This
zoonotic organism has historically been developed into a biological weapon. For this Tier 1 …

This collection of 10 articles in Frontiers and Cellular Microbiology aims to present the
current opportunities for development of innovative therapeutic strategies for tularemia, a …

Francisella tularensis is a facultative intracellular pathogen that causes the zoonotic disease
tularemia. Transmission can occur through arthropod vectors, by inhalation, ingestion, and …

Background The pathogenesis of Francisella tularensis, the causative agent of tularemia,
has been primarily characterized in mice. However, the high degree of sensitivity of mice to …