Innate immune cells, epithelial cells, and many other cell types are capable of detecting
infection or tissue injury, thus mounting regulated immune response. Inflammasomes are …

Inflammasomes are large multiprotein platforms that mediate the processing of caspase‐1,
which in turn promotes the maturation and release of IL‐1β and IL‐18 in response to …

The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and
non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8 …

Caspase-1 plays a fundamental role in innate immunity and in several important
inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β …

Caspase-1 is a unique cysteine protease playing central roles in innate immunity.
Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated …

The innate immune system represents the first line of defence against infectious agents, and
co-ordinates cellular and molecular mechanisms that result in effective inflammatory and …

Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-
like receptor (NLR) and PYHIN protein families in response to pathogen-associated …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Caspase-1 is an inflammatory caspase that is activated through formation of inflammasome
complexes in response to both pathogen-derived and endogenous mediators. The most well …

Caspases exert critical functions in diverse cell death pathways, including apoptosis and
pyroptosis, but some caspases also have roles in the processing of cytokines into their …