Evodiamine attenuates experimental colitis injury via activating autophagy and inhibiting NLRP3 inflammasome assembly

W Ding, Z Ding, Y Wang, Y Zhu, Q Gao… - Frontiers in …, 2020 - frontiersin.org
Autophagy and NLRP3 inflammasome were associated with the process of colitis. Drugs
targeting NLRP3 inflammasome and autophagy to treat colitis are absent, and they are …

[HTML][HTML] Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Q Lv, Y Xing, J Liu, D Dong, Y Liu, H Qiao… - … Pharmaceutica Sinica B, 2021 - Elsevier
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates
with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 …

[HTML][HTML] Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation

L Wang, Z Yu, C Wei, L Zhang, H Song, B Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The use of Trametes robiniophila Murr.(Huaier) as a complementary therapy for cancer has
recently become increasingly common in China. However, whether Huaier can regulate host …

Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling

W Wei, M Ding, K Zhou, H Xie, M Zhang… - Biomedicine & …, 2017 - Elsevier
It has been reported that the ethanol extract of Wedelia chinensis attenuates murine colitis.
Wedelolactone (WEL), a coumestane-type compound with many pharmacological activities …

[HTML][HTML] Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome

P Shen, Z Zhang, K Zhu, H Cao, J Liu, X Lu, Y Li… - Biomedicine & …, 2019 - Elsevier
Evodiamine (EVO), an extraction from the traditional Chinese medicine Evodia rutaecarpa,
has been reported to possess anti-inflammatory, anti-tumor and other pharmacological …

Evodiamine augments NLRP3 inflammasome activation and anti-bacterial responses through inducing α-tubulin acetylation

CG Li, QZ Zeng, MY Chen, LH Xu, CC Zhang… - Frontiers in …, 2019 - frontiersin.org
Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used
for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the …

[HTML][HTML] Esculentoside A could attenuate apoptosis and inflammation in TNBS-induced ulcerative colitis via inhibiting the nuclear translocation of NF-κB

Y Liu, W Wei, S Liang, H Fang, J Cao - Annals of translational …, 2022 - ncbi.nlm.nih.gov
Background Esculentoside A (EsA) has had a remarkable curative effect on a variety of
experimental acute and chronic inflammatory and autoimmune diseases. However, the role …

Low Dose of Deoxynivalenol Aggravates Intestinal Inflammation and Barrier Dysfunction Induced by Enterotoxigenic Escherichia coli Infection through Activating …

L Ge, D Liu, X Mao, S Liu, J Guo, L Hou… - Journal of Agricultural …, 2022 - ACS Publications
The toxicity of deoxynivalenol (DON) in healthy humans and animals has been extensively
studied. However, whether the natural-low-dose DON is scatheless under unhealthy …

Rubia cordifolia L. ameliorates DSS-induced ulcerative colitis in mice through dual inhibition of NLRP3 inflammasome and IL-6/JAK2/STAT3 pathways

W Qin, H Luo, L Yang, D Hu, SP Jiang, DY Peng… - Heliyon, 2022 - cell.com
The aerial part of​ Rubia cordifolia​ L. has been used as an herbal medicine for a long time
with various pharmacological activities, including anti-inflammatory, anticancer, and …

Munronoid I Ameliorates DSS-Induced Mouse Colitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Via Modulation of NLRP3

X Ma, Q Di, X Li, X Zhao, R Zhang, Y Xiao, X Li… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel diseases (IBDs) are increasingly common diseases characterized by
chronic and relapsing inflammation of the gastrointestinal tract. NLRP3 might be a crucial …