A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds
with therapeutic advantages over single target inhibitors and drug combinations. Inspired by …

On the basis of the synergism of topoisomerase (Top) and histone deacetylase (HDAC)
inhibitors in antitumor therapy, a series of novel Top/HDAC dual inhibitors were designed …

On the basis of synergistic effect between topoisomerase (Top) and histone deacetylase
(HDAC) inhibitors, a series of novel evodiamine-based Top/HDAC dual inhibitors were …

Due to the multimodal character of cancer, inhibition of two targets simultaneously by a
single molecule is a beneficial and effective approach against cancer. Histone deacetylase …

Histone deacetylases (HDACs) play a significant role in the proliferation and dissemination
of cancer and represent promising epigenetic drug targets. The HDAC inhibitor vorinostat …

Gastric cancer represents a significant health burden worldwide. Previously, inspired by the
traditional Chinese medicine Wu-Chu-Yu to treat the spleen and stomach system for …

In our study, three series of hydroxamate, 2-aminobenzamide, and trifluoromethyl ketone
analogues have been designed and synthesized. The synthesized compounds were …

In this work, we utilized the proteolysis targeting chimera (PROTAC) technology to achieve
the chemical knock-down of histone deacetylase 6 (HDAC6). Two series of cereblon …

Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …

A critical question in natural product-based drug discovery is how to translate the product
into drug-like molecules with optimal pharmacological properties. The generation of natural …