Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) possesses potent anti-
inflammatory effect. However, if TIPE2 ameliorates sciatic nerve injury (SNI)-induced …

Abstract TNF-α-inducible protein 8-like 2 (TIPE2) is a recently discovered regulator of
inflammation that can maintain immune homeostasis, exerting a significant role in the …

Spinal cord injury (SCI) is a devastating disease and causes tissue loss and neurologic
dysfunction, contributing to high morbidity and disability among human. However, the …

Abstract TIPE2 (TNF-α-induced protein 8-like 2) is a novel death effector domain protein and
is a negative regulator of the innate and adaptive immune response. Although it has been …

The endogenously activated rheumatoid arthritis (RA) synovial fibroblasts (RSFs) are likely
to be the key to curing the disease. RSFs express Toll‑like receptors (TLRs) rendering them …

TIPE2, also known as TNFAIP8L2, a member of the tumor necrosis factor-alpha-induced
protein-8 (TNFAIP8) family, is known as an inhibitor in inflammation and cancer, and its …

Rheumatoid arthritis (RA) is an autoimmune disease that leads to severe disabilities through
the induction of synovitis and subsequent cartilage and bone destruction. The development …

TIPE2, the tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TNFAIP8L2), plays an
essential role in maintaining immune homeostasis. It is highly expressed in macrophages …

Cholinergic anti-inflammatory pathway has therapeutic effect on inflammation-associated
diseases. However, the exact mechanism of nicotine-mediated anti-inflammatory effect is …

TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and
is involved in several inflammatory diseases. However, the immune inhibition mechanism of …