Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Aims: Neuropathic pain is a chronic debilitating disease that is often unresponsive to
currently available treatments. Emerging lines of evidence indicate that reactive oxygen …

Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for
its potential to treat various inflammatory diseases. However, the relationship of sesn2 with …

Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress.
Sesamol, a component of sesame oil, has anti‐inflammatory activity, but its mechanism in …

Abstract Background & Objective Sestrin2 (sesn2) has recently gained attention as an
important regulator for various metabolic disorders. Sesn2 is involved in AMP-activated …

Abstract Sestrin2 (Sesn2) exerts neuroprotective properties in some neurodegenerative
diseases. However, the role of Sesn2 in stroke is unclear. The AMP-activated protein …

Numerous studies have shown that mitochondrial dysfunction manifested by increased
mitochondrial permeability transition pore (mPTP) opening and reactive oxygen species …

Sestrin2 (SESN2), a highly conserved stress‐inducible metabolic protein, is known to
repress reactive oxygen species (ROS) and provide cytoprotection against various noxious …

Background Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia
are activated and polarized to either the pro-inflammatory M1 phenotype or anti …

Excessive differentiation of osteoclasts contributes to the disruption of bone homeostasis in
inflammatory bone diseases. Methyltransferase-like 3 (METTL3), the core methyltransferase …