Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity
JYC Park, A King, V Björk, BW English… - … of Physiology-Cell …, 2023 - journals.physiology.org
The extracellular matrix (ECM), composed of interlinked proteins outside of cells, is an
important component of the human body that helps maintain tissue architecture and cellular …
important component of the human body that helps maintain tissue architecture and cellular …
Reconstructing the ageing extracellular matrix
R Schnellmann, S Gerecht - Nature Reviews Bioengineering, 2023 - nature.com
The extracellular matrix (ECM) is a key component of the stem-cell niche, and undergoes
profound changes during ageing, affecting tissue mechanics and structure. Here, we argue …
profound changes during ageing, affecting tissue mechanics and structure. Here, we argue …
Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function
E Mavrogonatou, A Papadopoulou… - … of Physiology-Cell …, 2023 - journals.physiology.org
The extracellular matrix (ECM) is a dynamic structural network that provides a physical
scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus …
scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus …
The matrisome during aging and longevity: a systems-level approach toward defining matreotypes promoting healthy aging
CY Ewald - Gerontology, 2020 - karger.com
Accumulation of damage is generally considered the cause of aging. Interventions that delay
aging mobilize mechanisms that protect and repair cellular components. Consequently …
aging mobilize mechanisms that protect and repair cellular components. Consequently …
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …
providing structural support and stability to tissues. The understanding of the ECM and the …
Employing extracellular matrix-based tissue engineering strategies for age-dependent tissue degenerations
Tissues and organs are not composed of solely cellular components; instead, they converge
with an extracellular matrix (ECM). The composition and function of the ECM differ …
with an extracellular matrix (ECM). The composition and function of the ECM differ …
[HTML][HTML] Extracellular matrix dynamics as an emerging yet understudied hallmark of aging and longevity
The biomechanical properties of extracellular matrices (ECM) and their consequences for
cellular homeostasis have recently emerged as a driver of aging. Here we review the age …
cellular homeostasis have recently emerged as a driver of aging. Here we review the age …
Role of the extracellular matrix in stem cell maintenance
Abstract Purpose of Review Stem cells reside in specialized anatomical locations called
niches where supportive stromal cells and the extracellular matrix (ECM) regulate their self …
niches where supportive stromal cells and the extracellular matrix (ECM) regulate their self …
Extracellular matrix degradation and remodeling in development and disease
The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …
[HTML][HTML] All the small things: Nanoscale matrix alterations in aging tissues
Cellular aging stems from multifaceted intra-and extracellular molecular changes that lead to
the gradual deterioration of biological function. Altered extracellular matrix (ECM) properties …
the gradual deterioration of biological function. Altered extracellular matrix (ECM) properties …