All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

Glycerophospholipids are the most abundant membrane lipid constituents in most
eukaryotic cells. As a consequence, phospholipid class and acyl chain homeostasis are …

Yeast Pah1p phosphatidate phosphatase (PAP) catalyzes the penultimate step in the
synthesis of triacylglycerol. PAP plays a crucial role in lipid homeostasis by controlling the …

Zinc is an essential cofactor for many proteins. A key mechanism of zinc homeostasis during
deficiency is “zinc sparing” in which specific zinc-binding proteins are repressed to reduce …

Lipid biosynthesis and its regulation have been studied mostly in the nonoleaginous yeast
Saccharomyces cerevisiae that serves as a model for eukaryotic cells. On the other hand …

In yeast and higher eukaryotes, phospholipids and triacylglycerol are derived from
phosphatidate at the nuclear/endoplasmic reticulum membrane. In de novo biosynthetic …

Eukaryotic cells store neutral lipids such as triacylglycerol (TAG) in lipid droplets (LDs).
Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum …

The yeast Pah1p phosphatidate phosphatase, which catalyzes the penultimate step in the
synthesis of triacylglycerol and plays a role in the transcriptional regulation of phospholipid …

Phosphatidic acid (PA) phosphatase is an evolutionarily conserved enzyme that plays a
major role in lipid homeostasis by controlling the cellular levels of its substrate, PA, and its …

The Saccharomyces cerevisiae PAH1-encoded phosphatidate (PA) phosphatase, which
catalyzes the Mg 2+-dependent dephosphorylation of PA to produce diacylglycerol, is one of …