Analytical techniques in neuroscience: recent advances in imaging, separation, and electrochemical methods
How do we understand neuronal signaling in the brain, how neurons control behavior, or
how signaling malfunctions during disease? Neuroscientists might take two approaches …
how signaling malfunctions during disease? Neuroscientists might take two approaches …
Tracing superoxide anion in serotonergic neurons of living mouse brains with depression by small-molecule fluorescence probes
X Wang, F Che, X Zhang, P Li, W Zhang… - Analytical …, 2023 - ACS Publications
In brains, the serotonergic neurons are the unique resource of the neurotransmitter
serotonin, which plays a pivotal role in the physiology of the brain. The dysfunction of …
serotonin, which plays a pivotal role in the physiology of the brain. The dysfunction of …
Illuminating the monoamine transporters: Fluorescently labelled ligands to study dopamine, serotonin and norepinephrine transporters
GA Camacho‐Hernandez, K Jahan… - Basic & Clinical …, 2023 - Wiley Online Library
Fluorescence microscopy has revolutionized the visualization of physiological processes in
live‐cell systems. With the recent innovations in super resolution microscopy, these events …
live‐cell systems. With the recent innovations in super resolution microscopy, these events …
A photoswitchable inhibitor of the human serotonin transporter
B Cheng, J Morstein, LK Ladefoged… - ACS chemical …, 2020 - ACS Publications
The human serotonin transporter (hSERT) terminates serotonergic signaling through
reuptake of neurotransmitter into presynaptic neurons and is a target for many …
reuptake of neurotransmitter into presynaptic neurons and is a target for many …
Design and synthesis of 1-(3-(dimethylamino) propyl)-1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the …
AK Banala, P Zhang, P Plenge, G Cyriac… - Journal of medicinal …, 2013 - ACS Publications
The serotonin transporter (SERT) is the primary target for antidepressant drugs. The
existence of a high affinity primary orthosteric binding site (S1) and a low affinity secondary …
existence of a high affinity primary orthosteric binding site (S1) and a low affinity secondary …
Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools
JN Beaver, BL Weber, MT Ford, AE Anello, SK Kassis… - Cells, 2022 - mdpi.com
Plasma membrane monoamine transporter (PMAT, Slc29a4) transports monoamine
neurotransmitters, including dopamine and serotonin, faster than more studied monoamine …
neurotransmitters, including dopamine and serotonin, faster than more studied monoamine …
Novel and High Affinity Fluorescent Ligands for the Serotonin Transporter Based on (S)-Citalopram
V Kumar, T Rahbek-Clemmensen… - ACS medicinal …, 2014 - ACS Publications
Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and
evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine …
evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine …
Preconcentration and determination of solifenacin using hollow fiber microextraction coupled with HPLC
T Ashrafzadeh, M Qomi - Current Analytical Chemistry, 2016 - ingentaconnect.com
Background: Solifenacin is used for the treatment of overactive bladder. At present, a
number of separation and determination techniques, including high-performance liquid …
number of separation and determination techniques, including high-performance liquid …
Modular chemical probes for visualizing and tracking endogenous ion channels
ST McCarron, JJ Chambers - Neuropharmacology, 2015 - Elsevier
Fluorescently labeled, small molecule ligands designed for the labeling and tracking of
neuronal receptors have become an increasingly popular tool in neurobiology. The small …
neuronal receptors have become an increasingly popular tool in neurobiology. The small …
Optimization of extraction and pre-concentration of rizatriptan in biological samples using solvent bar and chemometrics design
Introduction: The acute treatment of migraine headaches is one of the major fields in which
rizatriptan is used. Materials and Methods: To determine rizatriptan in biological fluids, many …
rizatriptan is used. Materials and Methods: To determine rizatriptan in biological fluids, many …