Analytical techniques in neuroscience: recent advances in imaging, separation, and electrochemical methods

M Ganesana, ST Lee, Y Wang, BJ Venton - Analytical chemistry, 2017 - ACS Publications
How do we understand neuronal signaling in the brain, how neurons control behavior, or
how signaling malfunctions during disease? Neuroscientists might take two approaches …

Tracing superoxide anion in serotonergic neurons of living mouse brains with depression by small-molecule fluorescence probes

X Wang, F Che, X Zhang, P Li, W Zhang… - Analytical …, 2023 - ACS Publications
In brains, the serotonergic neurons are the unique resource of the neurotransmitter
serotonin, which plays a pivotal role in the physiology of the brain. The dysfunction of …

Illuminating the monoamine transporters: Fluorescently labelled ligands to study dopamine, serotonin and norepinephrine transporters

GA Camacho‐Hernandez, K Jahan… - Basic & Clinical …, 2023 - Wiley Online Library
Fluorescence microscopy has revolutionized the visualization of physiological processes in
live‐cell systems. With the recent innovations in super resolution microscopy, these events …

A photoswitchable inhibitor of the human serotonin transporter

B Cheng, J Morstein, LK Ladefoged… - ACS chemical …, 2020 - ACS Publications
The human serotonin transporter (hSERT) terminates serotonergic signaling through
reuptake of neurotransmitter into presynaptic neurons and is a target for many …

Design and synthesis of 1-(3-(dimethylamino) propyl)-1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the …

AK Banala, P Zhang, P Plenge, G Cyriac… - Journal of medicinal …, 2013 - ACS Publications
The serotonin transporter (SERT) is the primary target for antidepressant drugs. The
existence of a high affinity primary orthosteric binding site (S1) and a low affinity secondary …

Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools

JN Beaver, BL Weber, MT Ford, AE Anello, SK Kassis… - Cells, 2022 - mdpi.com
Plasma membrane monoamine transporter (PMAT, Slc29a4) transports monoamine
neurotransmitters, including dopamine and serotonin, faster than more studied monoamine …

Novel and High Affinity Fluorescent Ligands for the Serotonin Transporter Based on (S)-Citalopram

V Kumar, T Rahbek-Clemmensen… - ACS medicinal …, 2014 - ACS Publications
Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and
evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine …

Preconcentration and determination of solifenacin using hollow fiber microextraction coupled with HPLC

T Ashrafzadeh, M Qomi - Current Analytical Chemistry, 2016 - ingentaconnect.com
Background: Solifenacin is used for the treatment of overactive bladder. At present, a
number of separation and determination techniques, including high-performance liquid …

Modular chemical probes for visualizing and tracking endogenous ion channels

ST McCarron, JJ Chambers - Neuropharmacology, 2015 - Elsevier
Fluorescently labeled, small molecule ligands designed for the labeling and tracking of
neuronal receptors have become an increasingly popular tool in neurobiology. The small …

Optimization of extraction and pre-concentration of rizatriptan in biological samples using solvent bar and chemometrics design

Z Gerivani, N Ghasemi, M Qomi… - Current …, 2018 - ingentaconnect.com
Introduction: The acute treatment of migraine headaches is one of the major fields in which
rizatriptan is used. Materials and Methods: To determine rizatriptan in biological fluids, many …