The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention,
diagnosis and management must evolve as new treatment paradigms and disease …

Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Background The cumulative effect of taking multiple medicines with anticholinergic
properties termed as anticholinergic burden can adversely impact cognition, physical …

Globally, the number of drug prescriptions is increasing causing more adverse drug events,
which is now a significant cause of mortality, morbidity, and disability that has reached …

Chronic heart failure (CHF) is the leading cause of hospitalization for those over the age of
65 and represents a significant clinical and economic burden. About half of hospital re …

Obstructive sleep apnea syndrome (OSAS) is a common disorder with far-reaching health
implications. One of the major consequences of OSAS is an impact on neurocognitive …

Objective: in an effort to enhance medication prescribing for older adults and reduce the
burden of cognitive impairment, this paper reviews the literature regarding the negative …

There is evidence that postoperative cognitive dysfunction (POCD) is a significant problem
after major surgery, but the pathophysiology has not been fully elucidated. The interpretation …

Objective To assess the potential of anticholinergic drugs as a cause of non-degenerative
mild cognitive impairment in elderly people. Design Longitudinal cohort study. Setting 63 …

Background Despite the high intake of medications with anticholinergic properties by
community-dwelling elderly persons, the effects on cognitive decline and dementia have …