Telomere length and telomerase activity are important factors in the pathobiology of human
disease. Age-related diseases and premature ageing syndromes are characterized by short …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based
system. Telomerase maintains specific repetitive sequences, which protect chromosome …

The t-loop structure of mammalian telomeres is thought to repress nonhomologous end
joining (NHEJ) at natural chromosome ends. Telomere NHEJ occurs upon loss of TRF2, a …

The terminal t-loop structure adopted by mammalian telomeres is thought to prevent
telomeres from being recognized as double-stranded DNA breaks by sequestering the 3 …

A prerequisite for cellular immortalization in human cells is the elongation of telomeres
through the upregulation of telomerase or by the alternative lengthening of telomeres (ALT) …

When a telomere becomes unprotected or if only one end of a chromosomal double-strand
break succeeds in recombining with a template sequence, DNA can be repaired by a …

Little is known about the genes that regulate telomere length diversity between mammalian
species. A candidate gene locus was previously mapped to a region on distal mouse Chr …

Telomere replication is achieved through the combined action of the conventional DNA
replication machinery and the reverse transcriptase, telomerase. Telomere-binding proteins …