The key pathogenic event in prion disease involves misfolding and aggregation of the
cellular prion protein (PrP). Beyond this fundamental observation, the mechanism by which …

Olfactory deficits are present in numerous neurodegenerative disorders and are
accompanied by pathology in related brain regions. In several of these disorders, olfactory …

Auxiliary subunits are non-conducting, modulatory components of the multi-protein ion
channel complexes that underlie normal neuronal signaling. They interact with the pore …

Previous studies suggested that the cellular prion protein (PrPc) plays a critical role in the
pathogenesis of Alzheimer's disease (AD). Specifically, amyloid-β (Aβ) oligomers were …

Normal physiologic functions of the cellular prion protein (PrPc) are still elusive. This GPI‐
anchored protein exerts many functions, including roles in neuron proliferation …

Although the role of abnormal prion protein (PrP) conformation in generating infectious brain
diseases (transmissible spongiform encephalopathy) has been recognized, the function of …

The conversion of cellular prion protein (PrPc), a GPI-anchored protein, into a protease-K-
resistant and infective form (generally termed PrPsc) is mainly responsible for Transmissible …

Although many studies have investigated the function of cellular prion protein (PrPc), its
physiologic role remains elusive. PrPc null mice have been reported to develop normally …

Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone, secreted
from the enteroendocrine K cells, which has insulin-releasing and extra-pancreatic actions …

Agmatine, the primary decarboxylation product of L-arginine, generated from arginine
decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an …