Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Context: The term pseudohypoparathyroidism (PHP) indicates a group of heterogeneous
disorders whose common feature is represented by impaired signaling of various hormones …

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …

Recent advances in understanding the epidemiology, genetics, diagnosis, clinical
presentations, skeletal involvement, and therapeutic approaches to hypoparathyroidism led …

Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide
variety of key biological processes. It plays an essential role in cellular energy metabolism …

The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled
receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures …

Precocious puberty results mostly from the precocious activation of the gonadotropic axis.
Although the age limits have recently been discussed, most physicians consider that onset …

The GNAS complex locus encodes the alpha-subunit of the stimulatory G protein (Gsα), a
ubiquitous signaling protein mediating the actions of many hormones, neurotransmitters …

The G-protein-mediated signalling system has evolved as one of the most widely used
transmembrane signalling mechanisms in mammalian organisms. All mammalian cells …

GNAS is a complex imprinted gene that uses multiple promoters to generate several gene
products, including the G protein α-subunit (Gsα) that couples seven-transmembrane …