Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Targeting tumor-associated macrophages to synergize tumor immunotherapy

X Xiang, J Wang, D Lu, X Xu - Signal transduction and targeted therapy, 2021 - nature.com
The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …

Second near-infrared photothermal materials for combinational nanotheranostics

C Xu, K Pu - Chemical Society Reviews, 2021 - pubs.rsc.org
Second near-infrared photothermal therapy (NIR-II PTT, 1000–1500 nm) has recently
emerged as a new phototherapeutic modality with the advantages of deeper penetration …

Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 …

G Tan, C Huang, J Chen, F Zhi - Journal of hematology & oncology, 2020 - Springer
Background Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell
death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis …

The role of resveratrol in cancer therapy

JH Ko, G Sethi, JY Um, MK Shanmugam… - International journal of …, 2017 - mdpi.com
Natural product compounds have recently attracted significant attention from the scientific
community for their potent effects against inflammation-driven diseases, including cancer. A …

[HTML][HTML] Low dose ionizing radiation effects on the immune system

K Lumniczky, N Impens, G Armengol, S Candéias… - Environment …, 2021 - Elsevier
Ionizing radiation interacts with the immune system in many ways with a multiplicity that
mirrors the complexity of the immune system itself: namely the need to maintain a delicate …

[HTML][HTML] The molecular mechanisms of chemoresistance in cancers

HC Zheng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer
patients because chemoresistance causes recurrence, cancer dissemination and death …

Shared risk factors in cardiovascular disease and cancer

RJ Koene, AE Prizment, A Blaes, SH Konety - Circulation, 2016 - Am Heart Assoc
Cardiovascular disease (CVD) and cancer are the 2 leading causes of death worldwide.
Although commonly thought of as 2 separate disease entities, CVD and cancer possess …

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …