Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt
oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic …

The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of
cardiovascular disease and cancers. The main components of this diet include high intake of …

Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …

Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it
controls the correct segregation of chromosomes during mitosis. Many studies have focused …

Castration is the standard therapeutic treatment for advanced prostate cancer but with
limited benefit due to the profound relapse and metastasis. Activation of inflammatory …

Inflammation plays a key role in cancer initiation and propagation. Cyclooxygenase-2 (COX-
2) and 5-lipoxygenase (5-LOX), two important enzymes in inflammatory responses are up …

The cell division cycle 20 homologue (CDC20) is known to regulate the cell cycle. Many
studies have suggested that dysregulation of CDC20 is associated with various pathological …

Background: Estrogen-related receptor-α (ESRRA) is an orphan nuclear receptor,
expressing at high level in exuberant metabolism organs and acting as transcription factor …

Sesamin, a lipid-soluble lignan, is one of the major constituents of sesame. Previous studies
have reported that sesamin induces growth inhibition in human cancer cells, particularly …

Perturbations of the circadian clock are linked to multiple diseases, including cancers.
Pharmacological activation of REV-ERB nuclear receptors, the core components of the …