Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …
natural competition for the metal between bacterial pathogens and their human or animal …
Heme synthesis and acquisition in bacterial pathogens
Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …
essential to the function of hemoproteins, which are involved in energy generation by the …
Bacterial iron detoxification at the molecular level
JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - ASBMB
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …
[HTML][HTML] Heme uptake and utilization by gram-negative bacterial pathogens
KL Richard, BR Kelley, JG Johnson - Frontiers in cellular and …, 2019 - frontiersin.org
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …
Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia
FH Damron, AG Oglesby-Sherrouse, A Wilks… - Scientific reports, 2016 - nature.com
Determining bacterial gene expression during infection is fundamental to understand
pathogenesis. In this study, we used dual RNA-seq to simultaneously measure P …
pathogenesis. In this study, we used dual RNA-seq to simultaneously measure P …
Pseudomonas aeruginosa and its multiple strategies to access iron
IJ Schalk, Q Perraud - Environmental Microbiology, 2023 - Wiley Online Library
Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …
Quantitative Proteomics Reveals the Mechanism of Silver Nanoparticles against Multidrug-Resistant Pseudomonas aeruginosa Biofilms
Y Zhang, X Pan, S Liao, C Jiang, L Wang… - Journal of proteome …, 2020 - ACS Publications
The decline of clinically effective antibiotics has made it necessary to develop more effective
antimicrobial agents, especially for refractory biofilm-related infections. Silver nanoparticles …
antimicrobial agents, especially for refractory biofilm-related infections. Silver nanoparticles …
Extracellular heme uptake and the challenge of bacterial cell membranes
W Huang, A Wilks - Annual Review of Biochemistry, 2017 - annualreviews.org
Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …
Iron acquisition strategies in pseudomonads: mechanisms, ecology, and evolution
R Kümmerli - Biometals, 2023 - Springer
Iron is important for bacterial growth and survival, as it is a common co-factor in essential
enzymes. Although iron is very abundant in the earth crust, its bioavailability is low in most …
enzymes. Although iron is very abundant in the earth crust, its bioavailability is low in most …
Extracytoplasmic function sigma factors in Pseudomonas aeruginosa
S Chevalier, E Bouffartigues, A Bazire… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The opportunistic pathogen Pseudomonas aeruginosa, like all members of the genus
Pseudomonas, has the capacity to thrive in very different environments, ranging from water …
Pseudomonas, has the capacity to thrive in very different environments, ranging from water …