Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics

PE Klebba, SMC Newton, DA Six, A Kumar… - Chemical …, 2021 - ACS Publications
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Heme synthesis and acquisition in bacterial pathogens

JE Choby, EP Skaar - Journal of molecular biology, 2016 - Elsevier
Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

Bacterial iron detoxification at the molecular level

JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - ASBMB
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

[HTML][HTML] Heme uptake and utilization by gram-negative bacterial pathogens

KL Richard, BR Kelley, JG Johnson - Frontiers in cellular and …, 2019 - frontiersin.org
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia

FH Damron, AG Oglesby-Sherrouse, A Wilks… - Scientific reports, 2016 - nature.com
Determining bacterial gene expression during infection is fundamental to understand
pathogenesis. In this study, we used dual RNA-seq to simultaneously measure P …

Pseudomonas aeruginosa and its multiple strategies to access iron

IJ Schalk, Q Perraud - Environmental Microbiology, 2023 - Wiley Online Library
Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …

Quantitative Proteomics Reveals the Mechanism of Silver Nanoparticles against Multidrug-Resistant Pseudomonas aeruginosa Biofilms

Y Zhang, X Pan, S Liao, C Jiang, L Wang… - Journal of proteome …, 2020 - ACS Publications
The decline of clinically effective antibiotics has made it necessary to develop more effective
antimicrobial agents, especially for refractory biofilm-related infections. Silver nanoparticles …

Extracellular heme uptake and the challenge of bacterial cell membranes

W Huang, A Wilks - Annual Review of Biochemistry, 2017 - annualreviews.org
Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

Iron acquisition strategies in pseudomonads: mechanisms, ecology, and evolution

R Kümmerli - Biometals, 2023 - Springer
Iron is important for bacterial growth and survival, as it is a common co-factor in essential
enzymes. Although iron is very abundant in the earth crust, its bioavailability is low in most …

Extracytoplasmic function sigma factors in Pseudomonas aeruginosa

S Chevalier, E Bouffartigues, A Bazire… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The opportunistic pathogen Pseudomonas aeruginosa, like all members of the genus
Pseudomonas, has the capacity to thrive in very different environments, ranging from water …