Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase
DJ Deredge, W Huang, C Hui… - Proceedings of the …, 2017 - National Acad Sciences
A heme-dependent conformational rearrangement of the C-terminal domain of heme
binding protein (PhuS) is required for interaction with the iron-regulated heme oxygenase …
binding protein (PhuS) is required for interaction with the iron-regulated heme oxygenase …
The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and
virulence, yet this nutrient is sequestered by the innate immune system during infection …
virulence, yet this nutrient is sequestered by the innate immune system during infection …
Use of a multiplex transcript method for analysis of Pseudomonas aeruginosa gene expression profiles in the cystic fibrosis lung
AH Gifford, SD Willger, EL Dolben… - Infection and …, 2016 - Am Soc Microbiol
The discovery of therapies that modulate Pseudomonas aeruginosa virulence or that can
eradicate chronic P. aeruginosa lung infections associated with cystic fibrosis (CF) will be …
eradicate chronic P. aeruginosa lung infections associated with cystic fibrosis (CF) will be …
The small protein HemP is a transcriptional activator for the hemin uptake operon in Burkholderia multivorans ATCC 17616
T Sato, S Nonoyama, A Kimura, Y Nagata… - Applied and …, 2017 - Am Soc Microbiol
Iron and heme play very important roles in various metabolic functions in bacteria, and their
intracellular homeostasis is maintained because high concentrations of free forms of these …
intracellular homeostasis is maintained because high concentrations of free forms of these …
[HTML][HTML] Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport
AT Dent, A Wilks - Journal of Biological Chemistry, 2020 - ASBMB
Pseudomonas aeruginosa exhibits a high requirement for iron, which it can acquire via
several mechanisms, including the acquisition and utilization of heme. The P. aeruginosa …
several mechanisms, including the acquisition and utilization of heme. The P. aeruginosa …
[HTML][HTML] A Cationic Porphyrin, ZnPor, Disassembles Pseudomonas aeruginosa Biofilm Matrix, Kills Cells Directly, and Enhances Antibiotic Activity of Tobramycin
N Patel, S Swavey, J Robinson - Antibiotics, 2020 - mdpi.com
One of the greatest threats to human health is the rise in antibiotic-resistant bacterial
infections. Pseudomonas aeruginosa (PsA) is an “opportunistic” pathogen known to cause …
infections. Pseudomonas aeruginosa (PsA) is an “opportunistic” pathogen known to cause …
Axial heme coordination by the tyr-his motif in the extracellular hemophore hasap is critical for the release of heme to the HasR receptor of Pseudomonas aeruginosa
AT Dent, M Brimberry, T Albert, WN Lanzilotta… - Biochemistry, 2021 - ACS Publications
Pseudomonas aeruginosa senses extracellular heme via an extra cytoplasmic function σ
factor that is activated upon interaction of the hemophore holo-HasAp with the HasR …
factor that is activated upon interaction of the hemophore holo-HasAp with the HasR …
Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis
S Mouriño, A Wilks - Advances in microbial physiology, 2021 - Elsevier
Iron is an essential micronutrient for all bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, iron's toxicity combined with the need to maintain iron …
limited bioavailability. Furthermore, iron's toxicity combined with the need to maintain iron …
High-level expression of cell-surface signaling system Hxu enhances Pseudomonas aeruginosa bloodstream infection
F Yang, Y Zhou, P Chen, Z Cai, Z Yue, Y Jin… - Infection and …, 2022 - Am Soc Microbiol
Bloodstream infections (BSIs) caused by Pseudomonas aeruginosa are associated with a
high mortality rate in the clinic. However, the fitness mechanisms responsible for the …
high mortality rate in the clinic. However, the fitness mechanisms responsible for the …
Evidence for Porphyrin-Mediated Electron Transfer in the Radical SAM Enzyme HutW
Bacteria that infect the human gut must compete for essential nutrients, including iron, under
a variety of different metabolic conditions. Several enteric pathogens, including Vibrio …
a variety of different metabolic conditions. Several enteric pathogens, including Vibrio …