The gut microbiota, including bacteria, archaea, fungi, and viruses, compose a diverse
mammalian gut environment and are highly associated with host health. Bacteriophages …

Background Recent studies had provided evidence that the gut microbiota is associated with
sepsis. However, the potential causal relationship remained unclear. Methods The present …

There are significant differences in the susceptibility of populations to intestinal
ischemia/reperfusion (I/R), but the underlying mechanisms remain elusive. Here, we show …

The mortality rate associated with sepsis in elderly individuals is higher than that in younger
individuals. The intestinal microbiota has been demonstrated to play an important role in the …

Sepsis-induced myocardial dysfunction (SIMD) is a prevalent and severe form of organ
dysfunction with elusive underlying mechanisms and limited treatment options. In this study …

Background The morbidity and mortality of sepsis are extremely high, which is a major
problem plaguing human health. However, current drugs and measures for the prevention …

Aims The aim of this study was to investigate the protective effect of HLJDD on septic rats
and the underlying mechanisms. Materials and methods Adult male Sprague–Dawley (SD) …

Background Tetramethylpyrazine, an alkaloid extracted from Ligusticum chuanxiong Hort
(Umbelliferae), has been used in China for cardiovascular and cerebrovascular diseases …

Background Propofol is a widely used anesthetic and sedative, which has been reported to
exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno …