Inhibitors of histone deacetylases (HDACs) are nowadays part of the therapeutic arsenal
mainly against cancers, with four compounds approved by the Food and Drug …

Even though one is moving towards the success in the discovery of efficient anti-cancer
molecules, the drugs used in the treatment of various malignancies are found to possess …

Histone deacetylase (HDAC) enzymes regulate diverse biological function, including gene
expression, rendering them potential targets for intervention in a number of diseases, with a …

Conspectus For a long time, peptides were considered unsuitable for drug development due
to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However …

Histone deacetylases (HDAC) are a family of closely related enzymes involved in epigenetic
and posttranscriptional regulation of numerous genes and proteins. Their deregulation is …

Simple Summary Histone deacetylases (HDACs) are enzymes that control gene expression
and are involved in the onset of serious human pathologies, including cancer; hence, their …

Among numerous essential processes, memory and learning are important work of the
brain. Epigenetic manipulations through histone acetyltransferases (HATs) and histone …

Inhibition of histone deacetylase (HDAC) enzymes has emerged as a target for development
of cancer chemotherapy. Four compounds have gained approval for clinical use by the Food …

In this work, we report the multicomponent synthesis of a focused histone deacetylase
(HDAC) inhibitor library with peptoid-based cap groups and different zinc-binding groups. All …

Histone deacetylases (HDACs) are validated targets for treatment of certain cancer types
and play numerous regulatory roles in biology, ranging from epigenetics to metabolism …