Design, synthesis and molecular docking and ADME studies of novel hydrazone derivatives for AChE inhibitory, BBB permeability and antioxidant effects
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that is
characterized by memory and cognitive impairments that predominantly affects the elderly …
characterized by memory and cognitive impairments that predominantly affects the elderly …
[HTML][HTML] Design, Synthesis, and structure–activity relationships of thiazole analogs as anticholinesterase agents for Alzheimer's disease
Dementia is a neurological condition commonly correlated with Alzheimer's disease (AD),
and it is seen with many other central nervous system (CNS) disorders. The restricted …
and it is seen with many other central nervous system (CNS) disorders. The restricted …
Synthesis and Evaluation of a New Series of 3,5‐bis((5‐bromo‐6‐methyl‐2‐t‐aminopyrimidin‐4‐yl)thio)‐4H‐1,2,4‐triazol‐4‐amines and their Cyclized Products ' …
T Asghari, M Bakavoli, M Rahimizadeh… - Chemical Biology & …, 2015 - Wiley Online Library
A series of new 3, 5‐bis ((5‐bromo‐6‐methyl‐2‐t‐aminopyrimidin‐4‐yl) thio)‐4H‐1, 2, 4‐
triazol‐4‐amines and their cyclized products 'pyrimidinylthio pyrimidotriazolothiadiazines' …
triazol‐4‐amines and their cyclized products 'pyrimidinylthio pyrimidotriazolothiadiazines' …
Diversity-oriented heterocyclic synthesis using divergent reactivity of N-substituted iso (thio) cyanates
JF Vincent-Rocan, JS Derasp… - Chemical …, 2015 - pubs.rsc.org
Carbon-substituted isocyanates and isothiocyanates are common building blocks in organic
synthesis. In contrast, synthetic uses of N-substituted isocyanates and isothiocyanates are …
synthesis. In contrast, synthetic uses of N-substituted isocyanates and isothiocyanates are …
[HTML][HTML] Sequential MCR via Staudinger/Aza-Wittig versus Cycloaddition Reaction to Access Diversely Functionalized 1-Amino-1H-Imidazole-2(3H)-Thiones
A multicomponent reaction (MCR) strategy, alternative to the known cycloaddition reaction,
towards variously substituted 1-amino-1 H-imidazole-2 (3 H)-thione derivatives has been …
towards variously substituted 1-amino-1 H-imidazole-2 (3 H)-thione derivatives has been …
pKa Determination of Newly Synthesized N-(benzothiazole-2-yl)-2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)acetamide Derivatives
In this work, nine drug precursors, 2-(4, 5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-
(benzothiazole-2-yl) acetamide derivative compounds, were newly synthesized by reacting …
(benzothiazole-2-yl) acetamide derivative compounds, were newly synthesized by reacting …
Synthesis of spiro[indole-3,3′-[1,3,4]thiadiazino[3,2-a]benzimidazoles] and spiro[indole-3,6′-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines]
NI Gaponenko, AA Kolodina, AV Lesin… - Russian Chemical …, 2010 - Springer
A method for annulation of the tetrahydrothiadiazine ring to benzimidazoles and 1, 2, 4-tri-
azoles was developed. A number of earlier unknown [1, 3, 4] thiadiazino [3, 2-a] …
azoles was developed. A number of earlier unknown [1, 3, 4] thiadiazino [3, 2-a] …
Ionic‐liquid‐promoted Four‐component One‐pot Synthesis of Highly Functionalized Benzimidazo[2,1‐b][1,3]thiazines: Facile Construction of N‐fused Heterocycles
IR Siddiqui, A Srivastava, S Shamim… - Asian Journal of …, 2013 - Wiley Online Library
A one‐pot, four‐component, efficient, and facile synthesis of highly functionalized
benzimidazo [2, 1‐b][1, 3] thiazines promoted by ionic liquid ([bmim] Br)/Et3N has been …
benzimidazo [2, 1‐b][1, 3] thiazines promoted by ionic liquid ([bmim] Br)/Et3N has been …
A thorough study on the reaction of DMAD with 1-arylaminoimidazole-2-thiones. Expeditious synthesis of imidazo [2, 1-b][1, 3] thiazoles through a novel arylamino …
C Neochoritis, N Eleftheriadis, CA Tsoleridis… - Tetrahedron, 2010 - Elsevier
Upon reaction of 1-arylamino-imidazole-2-thiones 1 with dimethyl acetylenedicarboxylate
(DMAD) in the presence of 2.2 equiv of sodium hydride, imidazothiazoles 4 were exclusively …
(DMAD) in the presence of 2.2 equiv of sodium hydride, imidazothiazoles 4 were exclusively …
A tandem synthesis of 5-sulfonylimino-2-imidazolones from sulfonoketenimides and dialkyl azodicarboxylates
I Yavari, M Nematpour, E Ghanbari - Molecular diversity, 2014 - Springer
A tandem synthesis of 5-sulfonylimino-2-imidazolones from sulfonoketenimides and dialkyl
azodicarboxylates | SpringerLink Skip to main content Advertisement SpringerLink Log in …
azodicarboxylates | SpringerLink Skip to main content Advertisement SpringerLink Log in …