The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are
members of the nuclear receptor super-family, acting as ligand-inducible transcription …

It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

This review focuses on the contribution of white, brown, and perivascular adipose tissues to
the pathophysiology of obesity and its associated metabolic and vascular complications …

Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

The post-translational modification (PTM) of proteins (eg, phosphorylation, acetylation,
ubiquitinylation, SUMOylation) is a fundamental mechanism of cell signaling that modulates …

The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Glucocorticoid hormones (GCs) are important regulators of lipid metabolism, promoting
lipolysis with acute treatment but lipogenesis with chronic exposure. Conventional wisdom …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most
extensively studied transcription factors since its discovery in 1990, highlighting its …