Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung
cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of …

At the turn of the last century, the emerging field of medical oncology chose a cytotoxic
approach to cancer therapy over an immune-centered approach at a time when evidence in …

Missense mutations in p53 generate aberrant proteins with abrogated tumour suppressor
functions that can also acquire oncogenic gain-of-function activities that promote malignant …

Lung cancer is the leading cause of death by cancer in North America. A decade ago,
genomic rearrangements in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase …

In the past decade, the characterization of non-small-cell lung cancer (NSCLC) into
subtypes based on genotype and histology has resulted in dramatic improvements in …

Purpose To describe the emergence of targeted therapies that have led to significant
breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for …

The treatment of patients with advanced non–small cell lung cancer (NSCLC) harboring
chromosomal rearrangements of anaplastic lymphoma kinase (ALK) has been …

Chromosomal rearrangements that lead to oncogenic kinase activation are observed in
many epithelial cancers. These cancers express activated fusion kinases that drive the …