Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Within living cells, mitochondria are considered relevant sources of reactive oxygen species
(ROS) and are exposed to reactive nitrogen species (RNS). During the last decade …

Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and
their activity must meet cellular energy requirements, but the mechanisms that link organelle …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The mitochondrial permeability transition (PT)–an abrupt increase permeability of the inner
membrane to solutes–is a causative event in ischemia–reperfusion injury of the heart, and …

The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore
(PTP), a key effector of cell death, remains controversial. By combining highly purified, fully …

F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore
(PTP) but the mechanism (s) leading to channel formation remain undefined. Here, to shed …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

Mitochondria of all tissues convert various metabolic substrates into two forms of energy:
ATP and heat. Historically, the primary focus of research in mitochondrial bioenergetics was …