Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Nanoparticles (NPs) in biological fluids form a layer of biomolecules known as the protein
corona. The protein corona has been shown to determine the biological identity and in vivo …

Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all
organisms, and provides the reducing power for anabolic reactions and redox balance …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Background Epidemiological studies have shown Per-and polyfluoroalkyl substances
(PFAS) to be associated with diseases of dysregulated lipid and sterol homeostasis such as …