Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways
Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue
dysfunction. Numerous processes, including inflammation, myofibroblast activation, and …
dysfunction. Numerous processes, including inflammation, myofibroblast activation, and …
Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p
H Ni, W Li, Y Zhuge, S Xu, Y Wang, Y Chen… - International journal of …, 2019 - Elsevier
Abstract Background Circular RNAs (circRNAs) are emerging as powerful regulators of
cardiac development and disease. Nevertheless, detailed studies describing circRNA …
cardiac development and disease. Nevertheless, detailed studies describing circRNA …
Curcumin management of myocardial fibrosis and its mechanisms of action: a review
Y Yu, J Sun, R Wang, J Liu, P Wang… - The American Journal of …, 2019 - World Scientific
Myocardial fibrosis is implicated as a leading risk factor for heart failure, arrhythmia, and
sudden death after cardiac injury, as the excessive interstitial extracellular matrix impedes …
sudden death after cardiac injury, as the excessive interstitial extracellular matrix impedes …
[HTML][HTML] TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways
L Gao, L Wang, Z Liu, D Jiang, S Wu, Y Guo… - Cell death & …, 2020 - nature.com
Tissue nonspecific alkaline phosphatase (TNAP) is expressed widely in different tissues,
modulating functions of metabolism and inflammation. However, the effect of TNAP on …
modulating functions of metabolism and inflammation. However, the effect of TNAP on …
Characterization of a robust mouse model of heart failure with preserved ejection fraction
D Matsiukevich, A Kovacs, T Li… - American Journal …, 2023 - journals.physiology.org
Heart failure (HF) is a leading cause of morbidity and mortality particularly in older adults
and patients with multiple metabolic comorbidities. Heart failure with preserved ejection …
and patients with multiple metabolic comorbidities. Heart failure with preserved ejection …
[HTML][HTML] BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways
X Qu, Y Liu, D Cao, J Chen, Z Liu, H Ji, Y Chen… - Journal of Biological …, 2019 - ASBMB
Bone morphogenetic protein 10 (BMP10) is a cardiac peptide growth factor belonging to the
transforming growth factor β superfamily that critically controls cardiovascular development …
transforming growth factor β superfamily that critically controls cardiovascular development …
[HTML][HTML] CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia
W Liu, Y Wang, Z Qiu, R Zhao, Z Liu, W Chen, J Ge… - PeerJ, 2020 - peerj.com
Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia.
Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are …
Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are …
TNF‐Polarized Macrophages Produce Insulin‐like 6 Peptide to Stimulate Bone Formation in Rheumatoid Arthritis in Mice
The risk of osteoporosis is increased in rheumatoid arthritis (RA). Anti‐tumor necrosis factor
(TNF) therapy has markedly improved the outcomes of RA patients but does not improve …
(TNF) therapy has markedly improved the outcomes of RA patients but does not improve …
Pathological cardiac remodeling seen by the eyes of proteomics
DP Gomez-Mendoza, AC Lara-Ribeiro… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Cardiac remodeling involves cellular and structural changes that occur as consequence of
multifactorial events to maintain the homeostasis. The progression of pathological cardiac …
multifactorial events to maintain the homeostasis. The progression of pathological cardiac …
Compositions and methods for making and using three-dimensional tissue systems
2019-03-27 Assigned to RADISIC, MILICA reassignment RADISIC, MILICA ASSIGNMENT
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MIKLAS, Jason …
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MIKLAS, Jason …