Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways

HH Ng, M Shen, CS Samuel, J Schlossmann… - Molecular and cellular …, 2019 - Elsevier
Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue
dysfunction. Numerous processes, including inflammation, myofibroblast activation, and …

Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p

H Ni, W Li, Y Zhuge, S Xu, Y Wang, Y Chen… - International journal of …, 2019 - Elsevier
Abstract Background Circular RNAs (circRNAs) are emerging as powerful regulators of
cardiac development and disease. Nevertheless, detailed studies describing circRNA …

Curcumin management of myocardial fibrosis and its mechanisms of action: a review

Y Yu, J Sun, R Wang, J Liu, P Wang… - The American Journal of …, 2019 - World Scientific
Myocardial fibrosis is implicated as a leading risk factor for heart failure, arrhythmia, and
sudden death after cardiac injury, as the excessive interstitial extracellular matrix impedes …

[HTML][HTML] TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways

L Gao, L Wang, Z Liu, D Jiang, S Wu, Y Guo… - Cell death & …, 2020 - nature.com
Tissue nonspecific alkaline phosphatase (TNAP) is expressed widely in different tissues,
modulating functions of metabolism and inflammation. However, the effect of TNAP on …

Characterization of a robust mouse model of heart failure with preserved ejection fraction

D Matsiukevich, A Kovacs, T Li… - American Journal …, 2023 - journals.physiology.org
Heart failure (HF) is a leading cause of morbidity and mortality particularly in older adults
and patients with multiple metabolic comorbidities. Heart failure with preserved ejection …

[HTML][HTML] BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways

X Qu, Y Liu, D Cao, J Chen, Z Liu, H Ji, Y Chen… - Journal of Biological …, 2019 - ASBMB
Bone morphogenetic protein 10 (BMP10) is a cardiac peptide growth factor belonging to the
transforming growth factor β superfamily that critically controls cardiovascular development …

[HTML][HTML] CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

W Liu, Y Wang, Z Qiu, R Zhao, Z Liu, W Chen, J Ge… - PeerJ, 2020 - peerj.com
Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia.
Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are …

TNF‐Polarized Macrophages Produce Insulin‐like 6 Peptide to Stimulate Bone Formation in Rheumatoid Arthritis in Mice

X Yi, X Liu, HM Kenney, R Duan, X Lin… - Journal of Bone and …, 2020 - academic.oup.com
The risk of osteoporosis is increased in rheumatoid arthritis (RA). Anti‐tumor necrosis factor
(TNF) therapy has markedly improved the outcomes of RA patients but does not improve …

Pathological cardiac remodeling seen by the eyes of proteomics

DP Gomez-Mendoza, AC Lara-Ribeiro… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Cardiac remodeling involves cellular and structural changes that occur as consequence of
multifactorial events to maintain the homeostasis. The progression of pathological cardiac …

Compositions and methods for making and using three-dimensional tissue systems

J Miklas, M Radisic, N Thavandiran… - US Patent …, 2019 - Google Patents
2019-03-27 Assigned to RADISIC, MILICA reassignment RADISIC, MILICA ASSIGNMENT
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MIKLAS, Jason …