Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …
Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis
The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …
[HTML][HTML] Role of edaravone as a treatment option for patients with amyotrophic lateral sclerosis
HE Cho, S Shukla - Pharmaceuticals, 2020 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive
and fatal neurodegenerative disease that leads to a loss of muscle control due to nerve cells …
and fatal neurodegenerative disease that leads to a loss of muscle control due to nerve cells …
[HTML][HTML] Masitinib: The promising actor in the next season of the Amyotrophic Lateral Sclerosis treatment series
Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with high
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
SARM1, a protein with critical NADase activity, is a central executioner in a conserved
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
[HTML][HTML] Machine learning in amyotrophic lateral sclerosis: achievements, pitfalls, and future directions
V Grollemund, PF Pradat, G Querin, F Delbot… - Frontiers in …, 2019 - frontiersin.org
Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …
neurodegenerative condition with limited therapeutic options at present. Survival from …
Untargeted metabolomics yields insight into ALS disease mechanisms
Objective To identify dysregulated metabolic pathways in amyotrophic lateral sclerosis (ALS)
versus control participants through untargeted metabolomics. Methods Untargeted …
versus control participants through untargeted metabolomics. Methods Untargeted …
[HTML][HTML] NK cells associate with ALS in a sex-and age-dependent manner
BJ Murdock, JP Famie, CE Piecuch, KD Pawlowski… - JCI insight, 2021 - ncbi.nlm.nih.gov
NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex-
and age-specific manner was investigated. Herein, NK cells were depleted in male and …
and age-specific manner was investigated. Herein, NK cells were depleted in male and …
Motor neuron disease: pathophysiology, diagnosis, and management
LA Foster, MK Salajegheh - The American journal of medicine, 2019 - Elsevier
Patients with motor neuron diseases may present to primary care clinic or may be initially
encountered in the inpatient setting. Timely diagnosis of these conditions is a key factor in …
encountered in the inpatient setting. Timely diagnosis of these conditions is a key factor in …