Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Covering: up to June 2006This review article provides an overview on the current state of
research in the area of microtubule-stabilizing agents from natural sources, with a primary …

Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-
dependent tumor growth control or paradoxically accelerate tumor progression. The …

Emerging evidence suggests that cytotoxic therapy may actually promote drug resistance
and metastasis while inhibiting the growth of primary tumors. Work in preclinical models of …

Purpose: This study is aimed at investigating the role and novel molecular mechanisms of
galectin-1 in lung cancer progression. Experimental Design: The role of galectin-1 in lung …

Neoadjuvant chemotherapy (NAC) for rectal cancer (RC) shows promising clinical response.
The modulation of the tumor microenvironment (TME) by NAC and its association with …

BACKGROUND. Nuclear factor‐κB (NF‐κB), a key transcription factor thought to play a
major role in carcinogenesis, regulates many important signaling pathways involved in …

Purpose Increased expression of eicosanoids in cancer has been associated with adverse
prognosis. We performed a randomized phase II trial to test the hypothesis that inhibitors of …

Cancer cell resistance, particularly multidrug resistance (MDR), is the leading cause of
chemotherapy failure. A number of mechanisms involved in the development of MDR have …

Purpose Tumor overexpression of cyclooxygenase-2 (COX-2) has been associated with
worse outcome in non–small-cell lung cancer (NSCLC). In Cancer and Leukemia Group B …